ERP、EEG对盐酸多奈哌齐治疗血管性痴呆患者认知功能的评价  

The effect of ERP and EEG in assessing the donepezil to treat vascular dementia

作　　者：袁丰莲[1] 张冬梅[2] 

机构地区：[1]临沂市人民医院脑电图室,山东临沂276001 [2]临沂市人民医院神经内科,山东临沂276001

出　　处：《临床神经电生理学杂志》2008年第6期347-350,共4页Journal of Clinical Electroneurophysiology

摘　　要：目的:探讨事件相关电位(ERP)、脑电图(EEG)对盐酸多奈哌齐治疗血管性痴呆(VD)患者的认知功能和临床疗效的评价。方法:选取86例VD患者,随机分为盐酸多奈哌齐联合银杏叶制剂治疗组(多奈哌齐组)和单用银杏叶制剂治疗组(对照组),利用ERP、EEG、简易精神状况检查表(MMSE)和社会功能活动检查量表(FAQ)观察治疗前后认知功能和临床疗效的变化,并与对照组进行比较。结果:治疗3个月和6个月后,多奈哌齐组EEG、MMSE评分较对照组有显著改善(P<0.05),治疗6个月后,多奈哌齐组ERP、FAQ评分较对照组有显著改善(P<0.05)。结论:多奈哌齐治疗VD疗效显著;ERP、EEG结合MMSE是观察VD患者认知功能及临床疗效评价的有效方法。Objective:To explore the effect of ERP and EEG in assessing the donepezil to treat vascular dementia(VD).Methods: Eighty-six patients with VD were divided randomly into donepezil (conbined with ginko biloba)group and ginko biloba (pure)group.ERP、EEG、MMSE and FAQ were applied to assess the treatment with donepezil and ginko biloba.Results:After three months and six months treatment the dopenezil group’s MMSE and EEG were improved significantly as compared with the ginko biloba group(P<0.05).In the sixth m...

关 键 词：血管性痴呆(VD) 盐酸多奈哌齐 银杏叶制剂 事件相关电位(ERP) 脑电图(EEG) 简易精神状况检查表(MMSE) 

分 类 号：R749.16[医药卫生—神经病学与精神病学]