脑力智宝对东莨菪碱所致学习记忆获得障碍小鼠的保护作用  

Effect of Naoli Zhibao on Learning and Memory Acquired Disorder Induced by Scopolamine in Mice

作　　者：江雪华[1] 李锐[2] 周莉玲[2] 

机构地区：[1]暨南大学医学院,广东广州510632 [2]广州中医药大学中药学院,广东广州510405

出　　处：《中国实验方剂学杂志》2008年第10期42-44,共3页Chinese Journal of Experimental Traditional Medical Formulae

摘　　要：目的:探讨脑力智宝对东莨菪碱所致学习记忆获得障碍小鼠的保护作用与机制。方法:腹腔注射东莨菪碱制备学习记忆获得障碍模型小鼠,以跳台法观察脑力智宝对模型小鼠学习记忆能力的影响,并检测血清与脑内胆碱酯酶活性、脑内游离氨基酸的含量。结果:脑力智宝能显著改善模型小鼠的学习记忆能力,有效抑制血清及脑内胆碱酯酶的活性,并显著提高脑内谷氨酸(Glu)、天门冬氨酸(Asp)水平,降低γ-氨基丁酸(GABA)水平。结论:脑力智宝增强小鼠的学习记忆获得过程的作用机制可能与抑制胆碱酯酶合成、提高脑内Glu/GABA比值有关。Objective:To study the effect of Naoli Zhibao(NLZB) on learning and memory acquired disorder induced by Scopolamine.Methods:Scopolamine was injected intraperitoneally to induce learning and memory acquired disorder in mice.The learning and memory capability of mice was investigated by step-down test,the activity of acetylcholinesterase(AChE) in serum and brain and the contents of free amino acids were measured.Results:NLZB significantly promoted the learning and memory capability of mice,and depressed the a...

关 键 词：脑力智宝 学习记忆 胆碱酯酶 游离氨基酸 

分 类 号：R285.5[医药卫生—中药学]