青蒿总香豆素解热作用及其机理初步研究  

Preliminary Studies on Antipyretic Activity and Its Mechanisms of Total Coumarins from Artemisia annua

作　　者：宫毓静[1] 闫寒[1] 李爱媛[2] 赵一[2] 林启云[2] 李沧海[1] 

机构地区：[1]中国中医科学院医学实验中心,北京100700 [2]广西中医学院,广西南宁530001

出　　处：《中国实验方剂学杂志》2008年第12期49-52,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家重点基础研究发展计划课题(2006CB504701);北京市自然科学基金(7073094)

摘　　要：目的:研究青蒿总香豆素解热(降温)作用并探讨其作用机理。方法:从黄花蒿中提取总香豆素,利用内生致热原性家兔发热模型,观察青蒿总香豆素对发热家兔体温的影响并测定脑脊液、血清中前列腺素E2(PGE2)、环单磷酸腺苷(cAMP)水平以及肝脏、腓肠肌钠泵活性。结果:青蒿总香豆素可以显著降低正常及发热家兔体温,抑制肝脏、腓肠肌组织钠泵活性,降低发热家兔血液及脑脊液PGE2水平,对血液及脑脊液cAMP水平变化无明显影响。结论:香豆素成分可能是青蒿解热降温的有效部位,其作用机制与抑制钠泵活性及降低中枢PGE2水平有关。Objective:To study the antipyretic activity and related mechanisms of total coumarins(TCs) from Artemisia annua.Methods:Total coumarins were extracted from Artemisia annua using Spth method,rectal temperature(Tr) responses were observed in both normothermia and fever rabbits induced by endogenous pyrogens after intraperitoneal treatment of TCs,the concentration of cAMP and PGE_2 in either serum or cerebrospinal fluid of fever rabbits was measured by RIA,and Na^+,K^+-ATPase activity in liver and gastrocnemi...

关 键 词：黄花蒿 香豆素 发热 前列腺素E2 环单磷酸腺苷 钠泵 

分 类 号：R285.5[医药卫生—中药学]