肝硬化患者血清载脂蛋白ApoA_1和细胞因子水平与肝功能损伤的相关性探讨  

Study on the relationship between serum levels of ApoA_1,cytokines and severity of liver function impairment in patients with liver cirrhosis

作　　者：马慧霞[1] 叶力克西[2] 范淑英[1] 

机构地区：[1]新疆维吾尔自治区人民医院,乌鲁木齐830001 [2]新疆裕民县人民医院,834800

出　　处：《中国医药指南》2008年第22期31-32,共2页Guide of China Medicine

摘　　要：目的探讨了肝硬化患者血清载脂蛋白ApoA_1、可溶性L-Selection(L-选择素)和SICAM-I(细胞黏附分子-I)在肝硬化时造成肝功能损害过程中的作用。方法应用免疫比浊法和酶联免疫吸附法(ELISA法)对63例肝硬化患者进行了血清中载脂蛋白ApoA_1、L-选择素和SICAM-I水平检测及相关的肝功能生化指标进行相关分析,并与30例健康对照组比较。结果血清中载脂蛋白ApoA_1水平非常显著地低于健康对照组(P<0.01),而L-选择素、SICAM-I水平则显著高于健康对照组(P<0.01),且载脂蛋白ApoA_1水平与ALT(谷丙转氨酶)、TBIL(总胆红素)呈明显负相关,L-选择素、SICAM-I水平与ALT、TBIL呈明显正相关。结论检测肝硬化患者血清载脂蛋白ApoA_1、L-选择素和SICAM-I水平在一定程度上反映了机体的免疫功能状态和肝细胞损伤的程度,具有临床应用价值。Objective To explore the contributing role of serum ApoA_1,soluble L-selectin and ICAM-1 in the pathogenesis of liver function impairment in patients with liver cirrhosis.Methods Immunoturbidimetry was applied to measuring the serum level of ApoA_1,and ELISA was employed to detect soluble L-selectin and ICAM-1;meanwhile,the related hepatic function indicators (ALT and total bilirubim)were also examined in 63 patients with liver cirrhosis(liver cirrhosis group)and 30 healthy controls (control group).The resu...

关 键 词：肝硬化 栽脂蛋白ApoA_1 L-选择素 细胞黏附分子-Ⅰ 

分 类 号：R575.2[医药卫生—消化系统]