中药清热方干预治疗宫颈高危型HPV感染的对比研究  

The Study of in situ hybridization detection for cervical high-risk HPV and the intervention by traditional Chinese medicine

作　　者：徐侠[1] 张培影[1] 杨海燕[1] 鲍梅淑[1] 王旭波[1] 

机构地区：[1]南京中医药大学附属医院徐州市中医院

出　　处：《中国中医药现代远程教育》2008年第10期1167-1169,共3页Chinese Medicine Modern Distance Education of China

基　　金：江苏省中医药管理局科研课题[No:HZ07099]

摘　　要：目的探讨宫颈高危型HPV(16∕18型)感染与宫颈癌及癌前病变发生的相关性,分析中药清热解毒方干预和治疗HPV16∕18型感染的临床价值。方法运用原位杂交技术检测218例宫颈组织HPV16∕18型的表达水平,判定HPV16∕18型感染对宫颈癌及癌前病变的诊断价值;应用中药清热解毒扶正方干预和治疗HPV感染患者,并观察用药前后变化。结果218例患者HPV16∕18检出率分别为:CINⅠ16.67%(15∕90例)、CINⅡ48.43%(31∕64例)、CINⅢ91.11%、(41∕45例)、SCC84.21%(16∕19例);实验组52例,对HPV感染者用清热解毒、活血化瘀方剂局部熏蒸外洗和益气温阳、清热扶正方剂水煎口服,显效率44.23%(23∕52例);对照组显效率11.54%(6∕51例),两组间比较有显著性差异(P<0.01)。结论原位杂交技术检测HPV16∕18型对诊断宫颈癌及癌前病变具有早期、敏感、特异的特点;中药清热解毒扶正方干预、治疗HPV感染者疗效显著,若二者协同使用对宫颈癌和癌前病变的早期筛查与干预治疗,具有较高的临床使用价值和推广前景。Objective To explore the relativity of the in situ hybridization detection for cervical high-risk HPV (16/18 type) and cervical cancer and precancerous lesions.And to analyse the effect of intervention by traditional Chinese medicine.Method Giving the high-risk HPV-DNA detection to 218 female cases.The patients infected by HPV(16/18) were treated by Clearing away Heat and Reinforcing Body Resistance Prescription. Results The positive rate of HPV-DNA(16/18) was as follows:16.67% in CINI(15/90), 48.43% in CIN...

关 键 词：宫颈癌 人乳头瘤病毒(HPV) 原位杂交(ISH) 中药 干预 

分 类 号：R737.33[医药卫生—肿瘤]