被动吸烟大鼠脑血流动力学变化的实验研究  

Experimental Research about Cerebric Hemodynamic Change of Passive Smoking Rats

作　　者：孙晓红[1] 冯昱[2] 许爱华[2] 柳忠兰[2] 

机构地区：[1]中国医科大学附属第四医院神经内科,辽宁沈阳110032 [2]中国医科大学附属第一医院神经内科,辽宁沈阳110001

出　　处：《中国血液流变学杂志》2008年第4期474-475,493,共3页Chinese Journal of Hemorheology

摘　　要：目的研究被动吸烟大鼠颈动脉内皮细胞形态学与脑血流动力学的改变情况,探讨吸烟与脑血管病发生的关系。方法制备被动吸烟大鼠模型;应用透射电镜观察颈动脉内皮细胞的形态学变化,利用经颅彩色多普勒(TCD)测定脑血管血流动力学参数。结果1.吸烟组颈动脉内皮细胞正常超微结构被破坏。2.吸烟组脑血管Vs、Vd、Vm较对照组显著减慢(P<0.05),PI、RI显著增高(P<0.05)。结论吸烟通过引起血管内皮细胞的损伤与脑血流速度减慢、血管阻力增大,导致脑血管疾病的发生。Objective To observe the morphologic changes of vessel endothelial cell and effect of cerebric hemodynamics in passive smoking rat model.Exploring the relationship between cigarette smoking and cerebrovascular diseases.Methods Model of passive smoking rat was made.Morphologic changes of carotid artery endothelial cell were observed by transmission electron microscope.Parametes of cerebric hemodynamics were detected by transcranial color doppler.Results Compared with control group,the ultrastructures of vess...

关 键 词：吸烟 动物模型 血管内皮细胞 血流动力学 

分 类 号：R743.3[医药卫生—神经病学与精神病学]