高血压性脑出血患者血肿周围脑组织ICAM-1的表达及意义  

The Expression of Intercellular Adhesion Molecule-1 in the Perihematomal Tissues in Human Hypertensive Intracerebral Hemorrhage and Its Significance

作　　者：王春燕[1] 段淑荣[1] 赵庆杰[1] 

机构地区：[1]哈尔滨医科大学第一临床医学院神经内科,黑龙江哈尔滨150001

出　　处：《黑龙江医学》2009年第2期81-86,共6页Heilongjiang Medical Journal

基　　金：国家自然科学基金资助项目(30570617)

摘　　要：目的探讨脑出血后血肿周围组织细胞间黏附因子-1(Intercellular Adhesion Molecule-1,ICAM-1)的表达与脑水肿的关系。方法剖解39例脑出血后不同时间死亡病人的脑组织,自出血灶边缘向外1.0~3.0 cm及出血灶对侧相应部位的脑组织进行取材,出血灶对侧设为对照组。采用HE染色、免疫组化技术观察不同时间点出血灶周围ICAM-1在脑组织中的表达和变化规律。结果脑出血后2 h出血灶周围血管和神经细胞,即有ICAM-1的表达(2.12±0.32)个/高倍视野,17~24 h血肿周围ICAM-1阳性微血管数开始明显增加(6.02±1.05)个/高倍视野,72 h达到高峰(11.10±0.87)个/高倍视野,168~312 h后逐渐减弱(4.09±0.56)/高倍视野。此外,对侧脑实质内可见阳性神经细胞及少量ICAM-1阳性微血管。结论脑出血后,出血灶周围ICAM-1的表达增加,对脑出血后脑水肿的形成起着重要的促进作用。Objective To investigate the relationship between the expression of Intercellular Adhesion Molecule-1(ICAM-1) in the perihematomal tissues and the brain edema in human hypertensive intracerebral hemorrhage(ICH).Methods Paraffin-embedded brain tissues of 39 fatal cases ofhuman ICH were stained with HE and immunohistochemistry staining.The tissues were obtained from the perihematomal tissues 1.0～3.0 cm and the opposite regional tissues were used as control group.The expression changes of ICAM-1 in the perihem...

关 键 词：ICAM-1 脑水肿 高血压性脑出血 

分 类 号：R743.34[医药卫生—神经病学与精神病学]