基质金属蛋白酶抑制剂与胃癌新生血管形成的相关性研究  

Study on Relationship of NMPI and Angiogenesis in Gastric Cancer

作　　者：吕龙[1] 周晓庆[1] 魏谨[2] 

机构地区：[1]江苏省高淳县人民医院普外科,211300 [2]江苏省高淳县人民医院病理科,211300

出　　处：《中国误诊学杂志》2009年第4期764-766,共3页Chinese Journal of Misdiagnostics

摘　　要：目的:探讨TIMP-1、TIMP-2表达与胃癌新生血管形成的关系。方法:采用免疫组化方法分析83例胃癌石蜡标本中TIMP-1、TIMP-2的表达及新生血管密度(MVD),并应用图象分析的方法定量分析TIMP-1、TIMP-2在肿瘤中的表达及与MVD之间的关系。结果:无血管转移组MVD低于有血管转移组(P<0.05);低MVD组癌组织TIMP-2 MOD高于高MVD组,而TIMP-1则无显著性。结论:胃癌组织TIMP-2表达能抑制血管形成有关,而TIMP-1则无相关性。Objective:To evaluate the relation between the expression of TIMP-1,TIMP-2 and angiogenesis in gastric cancer.Methods:The expressions of TIMP-1 and TIMP-2 were quantitatively analyzed respectively with a computer-assisted of digitized microscopic images.Furthermore the relationship between the expression of TIMP-1,TIMP-2 and MVD was analyzed.Results:The MVD was significantly higher in positive vessel metastasis group than in the negative group(P<0.05),meanwhile the meanoptical density(MOD) lf TIMP-2 of c...

关 键 词：金属蛋白酶类组织抑制剂/代谢 胃肿瘤/代谢/病理学 新生血管化 病理性 人类 

分 类 号：R735.2[医药卫生—肿瘤]