顺铂和长春瑞滨联合放疗对大鼠脊髓损伤的实验研究  

Experimental study on injury of rat's spinal cord induced by radiotherapy combined with cisplatin and vinorelbine

作　　者：曲怡[1] 王媛媛[1] 吕广艳[2] 王若雨[3] 刘畅[4] 邹丽娟[1] 

机构地区：[1]大连医科大学附属第二医院肿瘤放疗科,辽宁大连116027 [2]大连医科大学分析测试中心,辽宁大连116044 [3]大连大学附属中山医院肿瘤科,辽宁大连116001 [4]中国医科大学,89期七年制辽宁沈阳110003

出　　处：《大连医科大学学报》2009年第1期9-13,共5页Journal of Dalian Medical University

摘　　要：[目的]探讨顺铂(cisplatin,DDP)和长春瑞滨(vinorelbine)联合放射治疗对大鼠脊髓损伤的影响。[方法]24只健康雄性Wistar大鼠随机分为4组:正常对照组;单纯放疗组;单纯化疗组;化疗联合放疗组。腹腔分别注射顺铂和长春瑞滨。直线加速器6 MeV电子线照射大鼠胸段脊髓,5 Gy/次,总剂量40 Gy。照射结束后5个月,光镜和电镜下观察脊髓的形态学改变。[结果]光镜下,单纯化疗组脊髓白质、灰质有轻微变化;单纯放疗组脊髓白质出现损伤;化疗联合放疗组脊髓白质、灰质均见明显损伤。电镜下,单纯放疗组髓鞘有轻微变化;单纯化疗组髓鞘有明显损伤;化疗联合放疗组髓鞘损伤严重。[结论]顺铂和长春瑞滨均可引起大鼠脊髓损伤,且顺铂和长春瑞滨联合放射治疗加重大鼠脊髓损伤。[Objective]To explore the injury of rat s spinal cord induced by radiotherapy combined with cisplatin and vinorelbine.[Methods] Twenty-four Wistar rats were randomly divided into 4 groups: normal group,radiotherapy group,cisplatin and vinorelbine group,and combination group.The rats were given cisplatin and ivinorelbine through intraperitoneal injection.The thoracic cord of rats were radiated by 6 MeV electron beam with 5.0 Gy each time and 40.0 Gy in total.Rats from each group were sacrificed after 5 month...

关 键 词：脊髓损伤 化学疗法 顺铂 长春瑞滨 放射疗法 

分 类 号：R730.5[医药卫生—肿瘤]