ERK_2在食管鳞状细胞癌组织中的表达及临床意义  

EXPRESSION AND CLINICAL SIGNIFICANCE OF ERK_2 IN ESOPHAGEAL SQUAMOUS CELL CARCINOMA

作　　者：曹立宇[1] 吴文清[1] 丁丽红[1] 潘美华[1] 张洪福[1] 

机构地区：[1]安徽医科大学病理教研室,合肥230032

出　　处：《中国组织化学与细胞化学杂志》2009年第1期59-63,共5页Chinese Journal of Histochemistry and Cytochemistry

摘　　要：目的研究ERK2在食管鳞状细胞癌组织中的表达及临床意义。方法应用免疫组化S-P法检测食管正常黏膜、癌旁组织及食管癌组织中ERK2表达状况。结果食管正常黏膜、癌旁组织及食管癌组织中ERK2表达率分别为20.0%(4/20)、45.7%(16/35)及86.2%(81/94),食管癌组织中ERK2表达率明显高于正常黏膜及癌旁组织组(P<0.05)。正常黏膜组和癌旁组织组ERK2表达率无明显差异(P>0.05),食管癌组织中ERK2表达与患者年龄、性别、肿瘤浸润深度、组织分化、淋巴结转移、临床分期及其它临床病理因素无关(P>0.05)。结论ERK2过表达在食管癌发生中起重要作用,单独检测ERK表达可能无助于判断患者的预后。Objective To study the expression and clinical significance of ERK2 in esophageal squamous cell carcinoma(SCC).Methods Using immunohistochemistry S-P method, the expression of ERK2 was examined in normal esophageal mucosa, pericancerous tissues and esophageal cancer tissues.Results The expression rates of ERK2 were 20.0% (4/20), 45.7%(16/35)and 86.2% (81/94)in normal esophageal mucosa, pericancerous tissues and esophageal cancer tissues, respectively. The expression rate of ERK2 in esophageal cancer tissues...

关 键 词：食道肿瘤 鳞状细胞癌 细胞外信号调节激酶 免疫组织化学 

分 类 号：R735.1[医药卫生—肿瘤]