慢性牙周炎与卟啉单胞菌、IL-1β和IL-6的关系  

The relationships of Porphyromonas gingivalis,IL-1β and IL-6 in chronic periodontitis

作　　者：党天毅 赵涯东[2] 赵东方[2] 

机构地区：[1]西安市铁路医院口腔科,710004 [2]西安交通大学口腔医院内科

出　　处：《中国厂矿医学》2009年第1期10-11,5,共3页Chinese Medicine of Factory and Mine

摘　　要：目的了解不同程度的慢性牙周炎牙龈卟啉单胞菌(Pg)检出率、龈沟液白细胞介素(IL)-1β和IL-6的含量,探讨其与慢性牙周炎发病机制的关系。方法分别用PCR技术和酶联免疫吸附试验(ELISA)检测113例慢性牙周炎患者龈下菌斑中的牙龈Pg和龈沟液中IL-1β、IL-6含量。结果轻度、中度和重度牙周炎患者的Pg检出率分别为40.6%、66.7%和87.2%,龈沟液中IL-1β含量分别为(13.08±6.7)、(38.25±18.5)、(45.25±21.3)pg/sample;IL-6含量分别为(14.16±7.6)、(40.25±20.8)、(46.30±19.4)pg/sample。中度和重度牙周炎患者的Pg检出率和龈沟液中IL-1β、IL-6含量与轻度牙周炎患者组存在统计学差异(P均<0.05)。结论Pg检出率和龈沟液中IL-1β、IL-6的含量能够反映慢性牙周炎的严重程度。Pg可能通过IL-1β、IL-6等炎性因子在慢性牙周炎中发挥作用。Objective To investigate the detection rate of Porphyromonas gingivalis(Pg) and the level of IL-1β,IL-6 in gingival crevicular fluid(GCF) of different degree chronic periodontitis and explore their relations with pathogenesis chronic periodontitis.Methods The Pg in dental plaque and the level of IL-1β,IL-6 in GCF of 113 cases of chronic periodontitis were measured by PCR and enzyme linked immunosorbent assay(ELISA).Results In mild,moderate and severe group,the detection rates of Pg in dental plaque were 40....

关 键 词：牙周炎 慢性 白细胞介素-1Β 白细胞介素-6 牙龈卟啉单胞菌 

分 类 号：R781.42[医药卫生—口腔医学]