血清血管内皮生长因子及CT灌注与原发性肝癌栓塞化疗的相关性分析  

The Analyses on the Correlation between Serum VEGF Level,CT Perfusion Imaging and TACE in Primary Hepatocarcinoma

作　　者：何斌[1] 邹文远[1] 陈光斌[1] 张自力[1] 石思李[1] 顾永丽[1] 

机构地区：[1]江西省妇幼保健医院放射科 郧阳医学院附属人民医院影像中心

出　　处：《实用放射学杂志》2009年第1期-,共4页Journal of Practical Radiology

摘　　要：目的探讨原发性肝癌(HCC)患者栓塞前后血清血管内皮生长因子(VEGF)水平和CT灌注参数之间的关系。方法对17例HCC患者于经导管动脉栓塞化疗(TACE)术前1d、术后7～10d分别采用酶联免疫吸附定量法测量血清VEGF水平,同时行CT灌注扫描,计算各函数图中肝血流量(HBF)、肝动脉灌注分数(HAF),肝动脉灌流量(HAP)、门静脉灌流量(PVP)。结果原发性肝癌栓塞前后的HBF、HAP存在显著差异,HAF、PVP、VEGF无显著差异。血清VEGF与HBF、HAF、HAP呈正相关,而与PVP无明显相关性。结论血清VEGF水平及CT灌注对评价肝癌TACE疗效、指导治疗有重要价值。Objective To investigate the correlation between serum level of vascular endothelial growth factor(VEGF) and CT perfusion imaging(CTPI) parameters before and after transcatheter hepatic arterial chemoembolization(TACE) in patients with hepatocellular carcinoma(HCC).Methods The serum level of VEGF was measured with the quantitative enzyme linked immunosorbent assay(ELISA) 1d before treatment and 7～10 d after TACE in 17 patients with HCC,and CTPI scans were performed in the same time.The perfusion parameters ...

关 键 词：肝脏 肝细胞癌 介入放射学 血管内皮细胞生长因子 体层摄影术 X线计算机 

分 类 号：R735.7[医药卫生—肿瘤]