褪黑素保护大鼠肝纤维化的机制初步研究  

A initial research on the mechanism of melatonin against rat liver fibrosis

作　　者：赵宗豪 梅俏[2] 吴军[2] 胡咏梅 徐新华[2] 许建明[2] 

机构地区：[1]安徽医科大学附属省立医院感染病科,合肥230001 [2]安徽医科大学第一附属医院消化内科,合肥230032

出　　处：《安徽医学》2009年第3期266-267,共2页Anhui Medical Journal

基　　金：国家教育部科学技术研究重点课题(编号:02068);安徽省自然基金项目(编号:01043904)

摘　　要：目的研究褪黑素保护大鼠肝纤维化的机制。方法用四氯化碳(CCl4)制造大鼠肝纤维化模型,同时予10mg/(kg.d)褪黑素腹腔注射;在造模的第3月末处死大鼠,用α-SMA单抗标记活化的肝脏星状细胞(HSC),并计算其数量,同时进行肝脏纤维化评分。结果褪黑素可以显著降低CCl4诱导大鼠肝脏纤维化评分,减少活化的HSC数量。结论褪黑素是通过抑制HSC的活化达到保护CCl4诱导的大鼠肝纤维化作用。Objective To study the mechanism of melatonin against rat liver fibrosis.Methods Rat liver fibrosis model was induced by carbon tetrachloride (CCl4), and meanwhile treated with melatonin i.p. at the dose of 10mg/kg body weight. The rats were killed at the end of 3rd month and the activated hepatic stellate cells(HSCs) labeled by α- smooth muscle actin (α-SMA)in the liver specimen were counted,the score of liver fibrosis was also measured.Results Melatonin decreased the score of rat liver fibrosis induced by...

关 键 词：褪黑素 肝硬化 机制 

分 类 号：R575.2[医药卫生—消化系统]