纳洛酮对血管性痴呆患者认知功能的影响  

Effect of naloxone on congnitive function of vascular dementia patients

作　　者：赵同[1] 张娴[1] 张荣芝[1] 

机构地区：[1]泰山医学院附属医院神经内科,山东泰安271000

出　　处：《泰山医学院学报》2009年第1期35-36,共2页Journal of Taishan Medical College

摘　　要：目的观察纳洛酮对血管性痴呆患者认知功能的影响。方法将80例多发性脑梗死血管性痴呆患者随机分为纳洛酮治疗组和常规药物治疗组,治疗组用常规药物疗法加纳络酮(0.8 mg+5%葡萄糖250 m l静脉点滴,每天1次),对照组仅用常规药物疗法,疗程均为15天。治疗前和治疗后15天、30天分别进行简明精神状态检查(MMSE)及长谷川改良痴呆量表(HDS-R)评分。结果治疗组治疗15天后与30天后与治疗前比较MMSE评分与HDS-R评分均有显著提高(P<0.05),而对照组无明显提高(P>0.05);治疗组治疗15天后与30天后比较则无显著性差异(P>0.05);治疗组在治疗15天后与30天后分别与同时间对照组比较MMSE评分与HDS-R评分有显著性差异(P<0.05)。结论应用纳洛酮可以显著改善血管性痴呆患者的认知功能,作用迅速,疗效显著。Objective: To observe the efficacy of naloxone on congnitive function of vascular dementia patients.Methods: Eighty patients with VD were assigned randomly to two groups.Forty patients in the test group were treated with Naloxone Hydrochloride and 40 patients in the control group were treated with routine medicinal treatment.Mini-mental state examination(MMSE) and improved Hasegawa Dementia Scale(HDS-R) score were used to estimate the therapeutic effect before and after the treatment for 15 days and 30 days...

关 键 词：纳洛酮 血管性痴呆 认知功能 

分 类 号：R749.13[医药卫生—神经病学与精神病学]