胃癌血管内皮生长因子C、D表达和淋巴结转移的关系  

Expression of Vascular Endothelial Growth Factor C、D and Their Relationship with Lymph Node Metastasis in Gastric Cancer

作　　者：郑重[1] 张明仪 

机构地区：[1]汕头大学医学院第二附属医院肝胆外科 [2]佛山市南海第二人民医院普通外科

出　　处：《肿瘤预防与治疗》2009年第1期9-12,117,共5页Journal of Cancer Control And Treatment

基　　金：吴阶平医学基金会临床科研资助基金(320.2710.0505)

摘　　要：目的:探讨血管内皮生长因子-C、D(VEGF-C、VEGF-D)在胃癌中的表达,及其与淋巴结转移的关系。方法:研究对象是100例胃癌手术病例,分淋巴结转移阳性组(n=50)和淋巴结转移阴性组(n=50),另设正常胃黏膜对照组(n=10)。应用免疫组织化学EnVisionTM两步法,检测正常胃黏膜和两组胃癌标本VEGF-C、VEGF-D表达。结果:在胃癌组织中,VEGF-C、VEGF-D呈阳性高表达,阳性表达率分别为51%、60%,与正常粘膜比较,胃癌中VEGF-C、VEGF-D阳性表达率更高(P<0.05)。在伴淋巴结转移的胃癌中,VEGF-C阳性表达率较无淋巴结转移者更高(P<0.005),VEGF-D阳性表达率在伴淋巴结转移的胃癌中与无淋巴结转移者比较,差异无统计学意义(P>0.05)。Logistic回归分析发现:在纳入的众多自变量多元分析中VEGF-C表达与胃癌区域淋巴结转移有强相关性(OR=14.292,标准回归系数=0.7937,P<0.0001),VEGF-D表达与胃癌区域淋巴结转移无相关性。结论:VEGF-C的高表达与胃癌淋巴结转移密切相关。Objective:Vascular endothelial growth factor C (VEGF-C) and D (VEGF-D) are considered to be potentially lymphangiogenic and can selectively induce hyperplasia of the lymphatic vasculature. In this study, we aimed to clarify the expressions of vascular endothelial growth factor C and D (VEGF-C,D) and their relationships with lymph node metastasis in gastric carcinoma.Methods: Using the specific antibodies of VEGF-C and D, we classified 100 cases which were treated by gastrectomy in 2004 into two groups (posi...

关 键 词：胃癌 血管内皮生长因子C、D 淋巴结 转移 

分 类 号：R735.2[医药卫生—肿瘤]