新辅助动脉灌注化疗在肢体骨肉瘤保肢治疗中的应用  

Application of neoadjuvant transarterial infusion chemotherapy combined with limb salvage surgery in treatment of limb osteosarcoma

作　　者：王胜涛[1,2] 李敏[1] 刘金君[3] 

机构地区：[1]山东省肿瘤防治研究院骨外科,山东济南250117 [2]济宁市任城区中医院疼痛科,山东济宁272100 [3]济宁市第一人民医院内科,山东济宁272100

出　　处：《中华肿瘤防治杂志》2008年第24期1895-1897,共3页Chinese Journal of Cancer Prevention and Treatment

摘　　要：目的:探讨新辅助动脉灌注化疗联合保肢手术在肢体骨肉瘤中的应用价值。方法:对38例肢体骨肉瘤患者采用多柔比星(ADM)50mg/m2、顺铂(DDP)70mg/m2和长春新碱(VCR)1.4mg/m2新辅助动脉灌注化疗联合保肢手术,比较同等剂量单纯静脉新辅助化疗联合保肢手术39例患者的临床疗效和组织学疗效。结果:动脉灌注化疗组临床有效率为79.0%,组织学有效率为92.1%;对照组临床有效率为56.4%,组织学有效率为69.2%。前者优于后者差异有统计学意义,P<0.05。结论:ADM、DDP和VCR新辅助动脉灌注化疗联合保肢手术是肢体骨肉瘤的有效方法,极具临床应用前景。OBJECTIVE: To investigate and evaluate the application of neoadjuvant transarterial infusion chemotherapy combined with limb salvage surgery in the treatment of limb osteosarcoma.METHODS: The transarterial infusion chemotherapy combined with limb salvage surgery was underwent on 38 patients with confirmed limb osteosarcoma and the simple intravenous transarterial chemotherapy combined with limb salvage surgery underwent on other 39 patients as the contrast,and both followed a ADM 50 mg/m2,DDP 70 mg/m2,and V...

关 键 词：灌注 局部 化学疗法 辅助 骨肿瘤/药物疗法 输注 动脉内 

分 类 号：R738.1[医药卫生—肿瘤]