经胃左动脉灌注化疗联合FOLFOX方案治疗晚期贲门癌临床观察  

Left gastric artery infusion combined with FOLFOX protocol for advanred cardia carcinoma patients

作　　者：张维浩[1] 王绍奎[1] 高磊[1] 

机构地区：[1]淄博市高青县人民医院肿瘤科,山东淄博256300

出　　处：《中华肿瘤防治杂志》2008年第24期1907-1908,共2页Chinese Journal of Cancer Prevention and Treatment

摘　　要：为了观察经胃左动脉灌注表柔比星(EPI)化疗联合FOLFOX方案治疗晚期贲门癌的疗效及不良反应,对21例晚期贲门癌患者应用经胃左动脉灌注EPI60mg/m2联合FOLFOX方案化疗〔(奥沙利铂(L-OHP)135mg/m2静脉滴入,d1;亚叶酸钙LV150mg/m2静脉推注,d1～d5;5-氟尿嘧啶(5-FU)500mg/m2静脉滴入,持续16h,d1～d5,21d为1个周期〕。至少2个周期后评价疗效及不良反应。21例患者均可评价疗效,共化疗78个周期,平均3.71个周期。其中CR1例,PR8例,NC9例,PD3例,CR+PR为42.9%,中位TTP为5.4个月,中位生存期8.2个月,1年生存率23.8%(5/21)。主要不良反应为骨髓抑制、脱发及神经性毒性。初步研究结果提示,经胃左动脉灌注EPI化疗联合FOLFOX方案治疗晚期贲门癌近期疗效肯定,不良反应轻微,患者耐受性良好。The objective of this study was to observe the clinical outcome of EPI by left gastric aretry infusion combined with FOLFOX protocol for cardia carcinoma.Twenty-one patients with advanced cardia carinoma were treated with EPI(60 mg/m2) combined with FOLFOX protocol.FOLFOX: L-OHP 135 mg/m2,iv.drip,d1;LV 150 mg/m2,iv.drip,d1-d5;5-FU 500 mg/m2,iv.drip,for 16 hours,d1-d5,21 days as one cycle.The treatment outcome was estimated at least two cycles later.Twenty-one patients were treated for 78 cycles,mean 3.71 cy...

关 键 词：胃肿瘤/药物疗法 表柔比星/药物疗法 综合疗法 

分 类 号：R735.2[医药卫生—肿瘤]