胰岛素抵抗与非酒精性脂肪性肝病关系的实验研究  

Experimental Research of the Relationship between Insulin Resistance and Non-alcoholic Fatty Liver Disease

作　　者：胡智阗[1] 车念聪[1] 夏蓉[1] 袁梦[1] 

机构地区：[1]首都医科大学中医药学院

出　　处：《首都医科大学学报》2009年第2期218-221,共4页Journal of Capital Medical University

基　　金：北京市教育委员会科技发展计划资助项目(KM200810025028)~~

摘　　要：目的探讨胰岛素抵抗(insulin resistance,IR)在非酒精性脂肪性肝病(non-alcoholic fatty liver disease,NAFLD)形成中的变化情况及两者间的关系。方法复制非酒精性脂肪性肝病大鼠模型,将其分为2组,即模型组与药物组,模型组造模后不给任何处理,药物组用罗格列酮合二甲双胍干预治疗。检测大鼠造模第2、4、6、8周末的空腹胰岛素、空腹血糖,计算胰岛素抵抗指数和胰岛素敏感指数。结果空腹血糖在各组间差异均无统计学意义。模型组和药物组在造模后第4周肝脏病理均检测提示形成NAFLD。模型组在造模后前两周没有出现明显的IR,从第4周末开始出现明显的持续外周IR状态;药物干预组在前4周无明显的IR,但第6周末和第8周末,出现了持续的IR。结论IR可能并不是NAFLD发生的唯一启动因素,可能是NAFLD产生的一个结果;运用胰岛素增敏剂对肝脏病理的改善并不确切,不能阻止NAFLD疾病的发生,需要进行深入的临床和实验研究。Objective To observe the insulin resistance(IR)changes in non-alcoholic fatty liver disease(NAFLD),and to investigate the relationship between IR and NAFLD.Methods Experimental animal models of NAFLD were established,which were treated with insulin sensitizer-Metformin and Rosiglitazone.Fasting blood glucose and fasting insulin were tested by the end of the second week,fourth,sixth and eighth week.Insulin resistance index and insulin sensitivity index were calculated.Results There wasn t a significant diffe...

关 键 词：非酒精性脂肪性肝病 胰岛素抵抗 

分 类 号：R575[医药卫生—消化系统]