不同浓度丝裂霉素C对准分子术后家兔角膜上皮下混浊形成的影响  

Effects of different concentration mitomycin C on preventing of haze in rabbits after epithelial keratectomileusis

作　　者：朱冬梅[1] 王新[1] 刘平[1] 李铮[1] 刘永瑞[1] 李金柳[1] 高延庆[1] 

机构地区：[1]郑州人民医院卓美眼科,郑州450003

出　　处：《郑州大学学报（医学版）》2009年第2期392-396,共5页Journal of Zhengzhou University(Medical Sciences)

摘　　要：目的:探讨丝裂霉素C(MMC)预防准分子激光上皮下角膜磨镶术(LASEK)后上皮下混浊(haze)的最低有效浓度。方法:90只成年日本大耳白兔常规行LASEK手术,根据术中应用MMC浓度的不同分为5组,第1～5组每组18只,右眼药物浓度分别为200.00、20.00、2.00、0.20、0.02mg/L,左眼未用药为对照组。于术后1周、1个月和3个月检查haze级别、角膜上皮、内皮,角膜取材电镜检查。结果:5组术后角膜上皮愈合时间均为3～4d,不同时间内皮细胞计数5组之间差异无统计学意义(P>0.05)。Haze形成第1～4组轻于第5组和对照组,差异有统计学意义(P<0.05),第5组与对照组比较差异无统计学意义(P>0.05)。电镜检查显示第1～4组术后角膜基质内成纤维细胞轻度活跃,到3个月时恢复正常,第5组、对照组术后基质内成纤维细胞增生明显活跃,持续时间超过3个月。结论:MMC可预防LASEK术后haze形成,最低有效浓度可达到0.20mg/L。Aim:To investigate the minimum effective concentration of mitomycin C (MMC) in preventing the haze of rabbit after laser epithelial keratectomileusis (LASEK).Methods:LASEK operation was carried out on 90 adult Japanese rabbits. Based on the different concentrations in operation,the rabbits were divided into 5 groups. From group 1 to group 5,each group had 18 rabbits with different concentrations (200.00,20.00,2.00,0.20,and 0.02 mg/L) on the right eye.There was no medicine on the left eye,which was used as a...

关 键 词：近视 准分子激光上皮下角膜磨镶术 丝裂霉素C 角膜上皮下混浊 兔 

分 类 号：R779.63[医药卫生—眼科]