余甘子对胰岛素抵抗大鼠过氧化物酶体增生物激活受体γ表达的影响  

Effects of Phyllanthus emblica L. Extract on Expression of Peroxisome Prolifemtor-activated Receptor γ (PPARγ) of Insulin Resistance Rat

作　　者：习雪峰[1] 崔节荣[1] 王勇[2] 

机构地区：[1]河南大学体育学院,河南开封475001 [2]三明学院体育系,福建三明365004

出　　处：《食品科学》2009年第5期253-256,共4页Food Science

摘　　要：目的:观察余甘子提取物对胰岛素抵抗大鼠脂肪细胞过氧化物酶体增生物激活受体γ(PPARγ)mRNA表达的影响。方法:Wistar大鼠30只,随机分为正常对照组10只,给予基础饲料;模型组20只,给予高脂饲料。模型组大鼠给予高脂喂养6w后,随机分为两个亚组:胰岛抵抗组(继续高脂饮食)和余甘子组(给予高脂饲料同时进行2ml剂量3.5g/kgbw余甘子提取物灌胃)。干预6w后,利用逆转录多聚酶链反应(RT-PCR)分别检测三组大鼠脂肪中PPARγ表达的差异。结果:高脂饮食成功诱导了胰岛素抵抗,余甘子提取物显著改善了胰岛素抵抗,胰岛素抵抗组大鼠的脂肪中PPARγ表达稍高于对照组,但显著低于余甘子组。结论:余甘子提取物明显改善胰岛素抵抗,可能与其提高PPARγmRNA表达有关。In this study, 30 male Wistar rats were randomly divided into the control group (n=10) which was fed basic diet, and the model group (n=20) which was fed high fat diet. After 6 weeks, the model group was randomly divided into 2 subgroups: insulin resistant group (n=10) which continued to receive high fat diet, and Phyllanthus emblica L. extract group (n=10) which was fed high fat diet and administered by gavage with 3.5 g/kg body weight of Phyllanthus emblica L. extract at the same time. After the treatment...

关 键 词：胰岛素抵抗 余甘子提取物 过氧化物酶体增生物激活受体Γ 脂联素 

分 类 号：R285.5[医药卫生—中药学]