神经元特异性烯醇化酶与脑损伤  

Neuron specific enolase and cerebral damage

作　　者：王中原[1] 陈光辉[1] 

机构地区：[1]南京军区南京总医院神经内科,江苏南京210002

出　　处：《医学研究生学报》2000年第4期250-253,共4页Journal of Medical Postgraduates

摘　　要：神经元特异性烯醇化酶 ( NSE)为烯醇化酶的γ二聚体同工酶 ,特征性地位于神经元和神经内分泌细胞胞质中 ,血清和脑脊液中亦含有少量 NSE。若神经元发生坏死 ,NSE会漏至胞外 ,使体液浓度升高。在脑损伤性疾病中 ,如脑梗死、脑出血、蛛网膜下腔出血、癫、脑外伤、脑缺氧、脑炎、Creutzfeldt-Jakob病 ,血清和 /或脑脊液 NSE显著升高 ,与脑损伤范围或疾病严重程度密切相关 。Neuron-specific enolase ( NSE, defined as -subunit of enolase ) is predominantly present in the plasma of neurons and neuroendocrine cells. Serum and cerebrospinal fluid (CSF ) also contain NSE at very low concentrations. If neurons die off, NSE will be released, into CSF and serum. Investigations showed that in many cerebral disorders,such as ischemic stroke,hemorrhagic stroke, epilepsia, head injury, encephalitis and Creutzfeldt-Jakob disease, NSE levels of serum and/or CSF elevated significantly.It reflected the severity of the disease or the extent of brain damage, predicted the outcome objectively and reliably.

关 键 词：烯醇化酶 神经元特异性 脑损伤 

分 类 号：R[医药卫生]