年龄相关性白内障的进展程度对角膜内皮细胞的影响的临床观察  

The Clinical Observation of the Effect of Age-Related Cataract Level on Corneal Endothelium

作　　者：徐宁[1] 康凤英[1] 杨媛[1] 

机构地区：[1]潍坊医学院眼科学教研室,山东潍坊261042

出　　处：《潍坊医学院学报》2009年第2期141-143,共3页Acta Academiae Medicinae Weifang

摘　　要：目的观察双眼进程不同的年龄相关性白内障患者角膜内皮细胞密度及形态学变化,探讨白内障进展程度对角膜内皮细胞的影响。方法选取视力一眼≤0.2,另一眼≥0.6年龄相关性白内障患者100例,视力≤0.2眼为A组,视力≥0.6眼为B组,分别对其双眼的角膜内皮细胞密度、细胞大小变异系数(CV)及六角形细胞比例进行检查。结果 A组角膜内皮细胞密度2297.65±364.66(cells/mm^2),变异系数(56.65±7.28)%,六角形细胞比例(35.06±5.45)%;B组角膜内皮细胞密度2570.46±340.25(cells/mm^2),变异系数(47.59±7.03)%,六角形细胞比例(41.97±5.19)%.A,B两组比较,角膜内皮细胞密度、角膜内皮细胞大小变异系数(CV)及六角形细胞比例差异有显著性(P<0.05)。结论随着年龄相关性白内障进展程度的加重,患者角膜内皮细胞密度降低、细胞大小变异系数增大、六角形细胞比例减少,显示角膜内皮细胞的损伤凋亡可能与白内障的进展有相关性。Objective To observe the corneal endothelium density and morph change and to approach the effect of age-related cataract level on corneal endothelium.Methods One hundred patients with age-related cataract whose one eye vision was lower than 0.2 and the other higher than 0.6.Each patient's two eyes were divided into two groups:the eye with vision lower than 0.2(A group) and the eye with vision higher than 0.6(B group).The two groups 'corneal endothelium density,coefficient of variation (CV) and percentages of hexagonal cell were observed and analyzed. Results In group A:the corneal endothelium density was 2297.65±364.66 (cells/mm^2),CV was(56.65±7.28) %,and Percentages of hexagonal cell was(35.06±5.45)%.In group B:the corneal endothelium density was 2570. 46±340.25 (cells/mm^2),CV was(47.59±7.03%),and Percentages of hexagonal cell was(41.97±5.19)%.There was statistical significance between the two groups in the above three indexes(P<0.05).Conclusion As the age-related cataract progresses,corneal endothelium density decreases,CV increases and percentages of hexagonal cell decreases. There is relationship between the damage of corneal endothelium and the progress of age-related cataract.

关 键 词：白内障 年龄相关性 角膜内皮细胞 视力 

分 类 号：R776.1[医药卫生—眼科]