国产奥美拉唑治疗肝源性溃疡临床对照研究  

Clinical Controlled Trial of China-produced Omeprazole in Treatment of Hepatogenic Ulcer

作　　者：黄赞松[1] 周喜汉[1] 尹毅霞[1] 

机构地区：[1]右江民族医学院消化疾病研究所消化内科,广西百色533000

出　　处：《中国自然医学杂志》2009年第3期202-204,共3页Chinese Journal of Natural Medicine

摘　　要：目的评价国产奥美拉唑对肝源性溃疡(HU)的疗效和副作用。方法对243例确诊肝硬化患者经胃镜检查有活动期溃疡患者46例,每日晨服国产奥美拉唑20 mg,疗程4~6周,观察胃镜下溃疡愈合、临床症状好转和副作用情况,并与同期消化性活动期溃疡(PU)43例对比。结果4周愈合率HU组中,十二指肠球部溃疡(DU)为71.43%(20/28),胃溃疡(GU)为55.56%(10/18);PU组中DU与GU为100.00%(31/31与12/12);两组比较差异有统计学意义(P<0.005)。6周愈合率HU中DU为85.71%(24/28),GU为88.89%(16/18)。肝功能Child C级者溃疡愈合率明显降低。结论国产奥美拉唑治疗HU的疗效较好,但比PU差,且疗程应比PU长,尤其肝功能Child C级者。未见明显副作用。Objective To evaluate the clinical efficacy and adverse effects of China-produced omeprazole on treatment of hepatogenic ulcer.Methods In 243 cases of definite cirrhosis of liver,46 patients with active ulcer diagnosed by gastroscope were given 20 mg of China-produced omeprazole every morning for 4 to 6 weeks.The healing rate of the ulcer,the remission of clinical symptoms and side effects of the above-mentioned patients were compared with those of 43 patients with peptic ulcer in active stage.Results After...

关 键 词：国产奥美拉唑 肝源性溃疡 肝功能 肝硬化 

分 类 号：R575.2[医药卫生—消化系统]