CYP2E1、GSTT1基因多态性与非霍奇金淋巴瘤易感性的关系  

Relationship between cytochrome P450 enzyme 2E1,glutathione S-transferase theta 1 genetic polymorphisms and non-Hodgkin lymphoma susceptibility

作　　者：宋宝[1] 刘杰[2] 郑劲松[3] 宋现让[1] 吕丽燕[1] 石艳[4] 

机构地区：[1]山东省肿瘤医院基础研究中心,济南250117 [2]山东省肿瘤医院内三科,济南250117 [3]山东省肿瘤医院PET室,济南250117 [4]山东大学齐鲁医院血液科,济南250012

出　　处：《山东大学学报（医学版）》2009年第7期57-60,共4页Journal of Shandong University:Health Sciences

摘　　要：目的探讨细胞色素P450酶2E1(CYP2E1)和谷胱甘肽硫转移酶(GSTT1)基因多态性与非霍奇金淋巴瘤(NHL)易感性的关系。方法分别采用聚合酶链反应-限制性片段长度多态性技术和聚合酶链反应技术对254例NHL患者和254例健康对照者CYP2E1和GSTT1基因多态性进行分析。结果NHL组和对照组CYP2E1基因多态性分布无明显差异(P>0.05);NHL组GSTT1基因缺失型频率明显高于对照组(48.0%vs 37.8%,P<0.05)。对NHL亚型分析显示,与GSTT1野生型者相比,携带GSTT1缺失型者发生弥漫大B细胞性淋巴瘤和滤泡性淋巴瘤风险分别为1.78倍(95%CI:1.12~2.82,P=0.02)和1.69倍(95%CI:1.03~2.77,P=0.04)。基因多态联合作用分析显示,CYP2E1野生型伴GSTT1缺失型者发生NHL的风险为1.83倍(95%CI:1.14~2.95,P=0.01)。结论GSTT1基因多态性可能是NHL的独立易感因素,GSTT1缺失型与CYP2E1野生型联合作用可进一步增加NHL的发病风险。Objective To explore the relationship between cytochrome P450 enzyme 2E1(CYP2E1),glutathione S-transferase theta 1(GSTT1) genetic polymorphism and individual susceptibility to non-Hodgkin lymphoma(NHL).Methods CYP2E1 genotypes were detected by the polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) technique in 254 patients with NHL and 254 healthy controls.GSTT1 genotypes were detected with the polymerase chain reaction(PCR) technique in the two groups. Results CYP2E1 gene polymorp...

关 键 词：非霍奇金淋巴瘤 基因多态性 细胞色素P450酶 谷胱甘肽硫转移酶 

分 类 号：R733.1[医药卫生—肿瘤]