Effect of Batroxobin on Expression of Neural Cell Adhesion Molecule in Temporal Infarction Rats and Spatial Learning and Memory Disorder  

作　　者：吴卫平 管兴志 匡培根 姜树军 扬炯炯 隋南 AlbertChen 匡培梓 张小澍 

机构地区：[1]Neurotransmitter Research Laboratory,Department of Neurology,Chinese PLA General Hospital,Postgraduate Military Medical School,Beijing 100853 [2]Institute of Psychology,Chinese Academy of Sciences,Beijing 100101 [3]PLA 261 Hospital,Beijing 100094,China

出　　处：《Journal of Traditional Chinese Medicine》2001年第4期294-298,共5页中医杂志（英文版）

摘　　要：The effect of Batroxobin expression of neural cell adhesion molecule (NCAM) in left temporal ischemic rats with spatial memory disorder was investigated by means of Morri's water maze and immunohistochemical methods. The results showed that the mean reaction time and distance of temporal ischemic rats for searching a goal were significantly longer than those of sham-operated rats and at the same time NCAM expression of left temporal ischemic region was significantly increased. However, the mean reaction time and distance of Batroxobin-treated rats were shorter and they used normal strategies more often and earlier than those of ischemic rats. The number of NCAM immune reactive cells of Batroxobin-treated rats was more than that of ischemic group. In conclusion, Batroxobin can improve spatial memory disorder of temporal ischemic rats and the regulation of the expression of NCAM is probably related to the neuroprotective mechanism.The effect of Batroxobin expression of neural cell adhesion molecule (NCAM) in left temporal ischemic rats with spatial memory disorder was investigated by means of Morri's water maze and immunohistochemical methods. The results showed that the mean reaction time and distance of temporal ischemic rats for searching a goal were significantly longer than those of sham-operated rats and at the same time NCAM expression of left temporal ischemic region was significantly increased. However, the mean reaction time and distance of Batroxobin-treated rats were shorter and they used normal strategies more often and earlier than those of ischemic rats. The number of NCAM immune reactive cells of Batroxobin-treated rats was more than that of ischemic group. In conclusion, Batroxobin can improve spatial memory disorder of temporal ischemic rats and the regulation of the expression of NCAM is probably related to the neuroprotective mechanism.

关 键 词：Animals BATROXOBIN Cell Adhesion Molecules  Neuronal Cerebral Infarction Male Maze Learning Memory Disorders Neuroprotective Agents Random Allocation RATS Rats  Wistar Temporal Lobe 

分 类 号：R743.33[医药卫生—神经病学与精神病学]