Effect of Batroxobin on Expression of C-Jun in Left Temporal Ischemic Rats with Spatial Learning and Memory Disorder  

作　　者：吴卫平 匡培根 姜树军 扬炯炯 隋南 匡培梓 张小澍 

机构地区：[1]Neurotransmitter Research Laboratory,Department of Neurology,Chinese PLA General Hospital,Postgraduate Military Medical School,Beijing 100853 [2]Institute of Psychology,Chinese Academy of Sciences,Beijing 100101 [3]PLA 261 Hospital,Beijing 100094

出　　处：《Journal of Traditional Chinese Medicine》2000年第2期147-151,共5页中医杂志（英文版）

摘　　要：The effect of Batroxobin on expression of c-Jun in left temporal ischemic rats with spatial memory disorder was investigated by means of Morri's water maze and immunohistochemistry methods. The results showed that the mean reaction time and distance of temporal ischemic rats for searching a goal were significantly longer than those of sham-operated rats, and at the same time c-Jun expression of left temporal ischemic region was significantly increased. However, the mean reaction time and distance of Batroxobin-treated rats were shorter and they used normal strategies more often and earlier than those of ischemic rats. The number of c-Jun immune reactive cells of Batroxobin-treated rats was also less than that of ischemic group. In conclusion, Batroxobin can improve spatial memory disorder in temporal ischemic rats, and the down-regulation of the expression of c-Jun is probably related to the neuroprotective mechanism.在左的 c6 月的表示上的 Batroxobin 的效果时间有空间存储器混乱的化学家老鼠借助于 Morri 的水迷宫和免疫组织化学被调查方法。结果证明吝啬的反应时间和距离时间是为寻找一个目标的老鼠是的化学家比那些显著地长假冒操作老鼠，并且同时左的 c6 月表示时间化学家区域显著地被增加。然而，对待 Batroxobin 的老鼠的吝啬的反应时间和距离更短，他们比那些更经常并且早使用了正常策略是化学家老鼠。c6 月的数字对待 Batroxobin 的老鼠的有免疫力的反应房间也是不到的化学家组。在结论， Batroxobin 能改进空间记忆混乱在时间是化学家老鼠，并且 c6 月的表示的下面规定可能与 neuroprotective 机制有关。

关 键 词：Genes  jun Animals BATROXOBIN Gene Expression Hypoxia-Ischemia  Brain Male Memory Disorders Proto-Oncogene Proteins c-jun Random Allocation RATS Rats  Wistar Temporal Lobe 

分 类 号：R743[医药卫生—神经病学与精神病学]