焦虑症患者感觉门控的研究  

Study of Sensory Gating in Patients with Anxiety Disorder

作　　者：楼翡璎[1] 陈兴时[1] 张明岛[1] 王红星[1] 梁建华[1] 陈冲[1] 

机构地区：[1]上海市精神卫生中心,上海200030

出　　处：《神经病学与神经康复学杂志》2008年第2期80-81,118,共3页Journal of Neurology and Neurorehabilitation

摘　　要：目的了解焦虑症的听觉诱发电位 P50特点。方法应用美国 Nicolet Bravo 脑电生理仪,采用听觉条件刺激(S1)-测试刺激(S2)模式对36例焦虑症患者和45名正常人作了听觉 P50检测。结果 (1)焦虑症 P50抑制明显减弱;S2-P50波幅正常人(2.2±0.9)μV,患者组(2.8±1.8)μV,P<0.05。(2)与正常对照组相比,焦虑症组 S1-P50降低(S1-P50正常组(5.2±3.1)μV,患者组(3.9±1.2)μV,P<0.05)。(3)P50抑制明显减弱,即 S1-S2比值明显降低(正常组3.0±1.9,患者组1.1±2.4,P<0.01)。结论焦虑症的感觉门同样也存在异常,表现为抑制不足,能通过听觉 P50进行定量检测。Objective To observe the characteristics of sensory gating P50 in patients with anxiety disorder. Methods Auditory evoked potentials P50 were recorded in 45 normal controls and 36 anxiety disorder patients by the conditioning/testing paradigm presented with auditory double clicks stimuli,using American Nicolet Bravo instru- ment.Results Compared with normal controls,anxiety disorder patients showed decreased S1-P50 amplitude(NC: 5.2±3.1 μV,anxiety disorder:3.9±1.2 μV,P<0.05),increased S2-P50 amplitude(NC:2.2±0.9 μV,anxi- ety disorder:2.8±1.8 μV,P<0.05),and decreased S2-S1(NC:3.0±1.9,anxiety disorder:1.1±2.4,P< 0.01),suggesting patients have sensory gating deficits.Conclusion The anxiety disorder patients had sensory ga- ting deficits,reflecting by auditory evoked potential PS0.

关 键 词：焦虑症 感觉门 P50 诱发电位 听觉 

分 类 号：R749.72[医药卫生—神经病学与精神病学] R741.044[医药卫生—临床医学]