家兔不同程度颈动脉狭窄模型的建立及评价  

Establishing and Evaluating a Rabbit Model with Carotid Stenosis of Various Degrees

作　　者：郑冲[1] 吴钢[1] 阮琴韵[1] 陈济铭[1] 郑依勇[1] 魏慧星[1] 

机构地区：[1]福建医科大学附属第一医院神经内科,福建省福州市350005

出　　处：《中国卒中杂志》2008年第2期98-103,共6页Chinese Journal of Stroke

摘　　要：目的建立一种颈动脉狭窄模型,并对狭窄处的血液动力学进行分析。方法用缝线将颈动脉与不同管径的塑料管结扎,形成不同程度颈动脉狭窄家兔模型,而后用数字减影血管造影(DSA)评价狭窄程度,用经颅多普勒(TCD)超声评价狭窄后血液动力学变化。结果DSA检查狭窄率(CCA法)轻度为30%,中度为59%,重度为84%;TCD能清楚地检测到造模前后颈动脉血液动力学情况,造模后搏动指数(PI)和阻力指数(RI)均降低(除了重度狭窄的近端);三种狭窄程度下均可见狭窄近端血流速度减低,PI和RI升高,狭窄处血流速度明显升高,RI和PI减低,狭窄远端血流速度、PI和RI均减低。结论本实验建立的不同程度颈动脉狭窄模型,成模时间短,狭窄程度稳定,能够方便用于血管狭窄后的血液动力学分析,是一种较为理想的以分析血液动力学变化为目的的颈动脉狭窄模型。Objective To establish a carotid stenosis model which is convenient for evaluating the hemodynamics of stenosis arteries. Methods By using suture,we bound the carotid arteries with plastic tubes in different calibers to establish the carotid stenosis model in various degrees,and then to evaluate the stenosis with digital subtraction angiography (DSA) and the hemodynamics with transcranial Doppler sonography (TCD). Results In the DSA results(CCA criterion),the light was 30%,the moderate 59%,the severe 84%; In TCD results,we could clearly detect the hemodynamics before and after establishing the models and the pulsatility index(PI) and resistance index(RI) both reduced after establishing the models except the proximal of the severe. But in all models we could find that in the proximal of stenosis the blood velocity reduced and the PI and RI increased; in the spot of stenosis,the blood velocity increased while the PI and RI reduced; in the distal of stenosis,the blood velocity,PI and RI also reduced. Conclusion Using our method we can establish a stenosis model quickly,stably and the hemodynamics are convenient to be detected. These models are more ideal to evaluate the hemodynamics in the carotid stenosis.

关 键 词：颈动脉狭窄 血管造影 血液动力学 兔 

分 类 号：R743.3[医药卫生—神经病学与精神病学]