Subchronic toxicological effects of aquatic nitrobenzene on Medaka and Chinese rare minnow  

作　　者：ZHOU QunFang1, FU JianJie1,2, MENG HaiZhen1,2, ZHU XueYan1,2, JIANG GuiBin1, ZHANG JianBin1, LIU JieMin2 & SHI GuoQing2 1 State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China 2 Department of Chemistry, School of Applied Science, University of Science and Technology Beijing, Beijing 100083, China 

出　　处：《Science China Chemistry》2007年第5期707-717,共11页中国科学（化学英文版）

基　　金：Supported by the National Natural Science Foundation of China (Grant Nos. 40503014 and 40590392);Chinese Academy of Sciences (Grant No. KJCX2-SW- H06, KZCX2-YW-402);Beijing Nova Programme (Grant No. 2004A51)

摘　　要：Based on the simulative exposure experiments of nitrobenzene to two small experimental fishes, Medaka (Oryzias latipes) and Chinese Rare Minnow (Gobiocypris rarus), it was found that nitrobenzene could decrease in a linear way in the static aquatic system. Both fishes could accumulate dose-related levels of nitrobenzene quickly and eliminate the compound rapidly when they were transferred to clean water. The Chinese rare minnow showed more sensitivity to the acute toxicity exposure of nitrobenzene than Medaka. Typical molecular biomarkers in oxidative defense system including superoxide dismu- tase (SOD), catalase (CAT) showed the chemical induced alterations. The changes of acetylcholi- nesterase (AChE) activities indicated that nitrobenzene might affect the normal neural function. Nitro- benzene exposure could also lead to obvious damaging effects on the target organs, such as gill and liver by hitopathological studies.Based on the simulative exposure experiments of nitrobenzene to two small experimental fishes, Medaka (Oryzias latipes) and Chinese Rare Minnow (Gobiocypris rarus), it was found that nitrobenzene could decrease in a linear way in the static aquatic system. Both fishes could accumulate dose-related levels of nitrobenzene quickly and eliminate the compound rapidly when they were transferred to clean water. The Chinese rare minnow showed more sensitivity to the acute toxicity exposure of nitrobenzene than Medaka. Typical molecular biomarkers in oxidative defense system including superoxide dismu- tase (SOD), catalase (CAT) showed the chemical induced alterations. The changes of acetylcholi- nesterase (AChE) activities indicated that nitrobenzene might affect the normal neural function. Nitro- benzene exposure could also lead to obvious damaging effects on the target organs, such as gill and liver by hitopathological studies.

关 键 词：nitrobenzene  Medaka  CHINESE RARE minnow  bioaccumulation  elimination  molecular biomarkers  histopathological effects 

分 类 号：X174[环境科学与工程—环境科学]