59例急性有机磷中毒救治过程中阿托品中毒的临床分析  

Clinical analysis of atropine poisoning in rescue of acute organophosphorus pesticide poisoning:report of 59 cases

作　　者：刘利峰[1] 夏鹄[1] 刘先华[1] 吴航滨[1] 董喜英[1] 

机构地区：[1]解放军306医院急诊部,北京100101

出　　处：《中国急救复苏与灾害医学杂志》2007年第7期391-392,396,共3页China Journal of Emergency Resuscitation and Disaster Medicine

摘　　要：目的探讨抢救急性有机磷农药中毒(AOPP)过程中阿托品中毒的发生率和临床表现。方法59例AOPP患者接受常规洗胃,应用胆碱脂酶复能剂,对症支持治疗,并尽早应用阿托品。分析其转归。结果25例(42·37%)出现不同程度的阿托品中毒,阿托品中毒前1h阿托品用量为28·16±21·92mg。全部出现皮肤干燥,心率>130次/分,20例(80%)出现躁动。阿托品中毒与非中毒者的瞳孔大小无显著性差异。结论应用较大剂量阿托品后,瞳孔的大小与阿托品用量的相关性不大。小躁动的出现说明阿托品用量到位。Objective To investigate the incidence and clinical features of atropine poisoning in rescue of acute organophosphorus pesticide poisoning.Methods 59 patients of AOPP underwent routine gastric lavage,expectant treatment,and treatment of cholinesterase reactivator and atropine as early as possible.The incidence and clinical manifestations of atropine poisoning were analyzed.Results Twenty-five cases(42.37%) suffered from atropine poisoning for which the dose of atropine 1h before poisoning was 28.16±21.92 mg.All patients showed dry skin and a heart rate>130 beats/minute.Twenty patients showed restlessness.There was no significant difference in the size of pupils between the patients with and without atropine poisoning.Two patients with atropine poisoning died.Conclusion When atropine is used at a rather high dose,the pupil size is not significantly correlated with the atropine dose.Restlessness signifies that atropine has been administered sufficiently.

关 键 词：有机磷中毒 阿托品中毒 

分 类 号：R[医药卫生]