长托宁与阿托品治疗急性有机磷农药中毒疗效比较研究  

Comparative study of curative effects of penehyclidine hydrochloride and atropine in treating acute organophosphorus pesticide poisoning

作　　者：何宗保[1] 嵇霆[1] 柯蕾[1] 

机构地区：[1]安徽省立医院急救医学中心急诊内科,合肥230001

出　　处：《中国急救复苏与灾害医学杂志》2007年第9期520-522,共3页China Journal of Emergency Resuscitation and Disaster Medicine

摘　　要：目的比较长托宁与阿托品治疗急性有机磷农药中毒的疗效。方法56例急性有机磷农药中毒患者随机分为例数相等的两组,分别接受长托宁(1～3mg)或阿托品(首次剂量1～10mg)治疗,均伍用氯磷定,至症状基本消失及全血胆碱酯酶活力恢复到60%以上。结果长托宁治疗组仅发生中间综合征1例,痊愈27例;对照组反跳2例,药物过量5例,痊愈23例。长托宁组的并发症发生率显著低于对照组(P<0.01)。结论长托宁治疗组优于阿托品对照组。Objective To compare the curative effects between penehyclidine hydrochloride (PQN) and atropine in treating acute organophosphorus pesticide poisoning (AOPP). Methods Fifty-six AOPP patients were randomly assigned to 2 equal groups to be treated with PQN or atropine as control group. Both PQN and atropine were used in combination with paralidoxime chloride. The treatment last until the clinical manifestation of AOPP basically disappeared and the blood cholinesterase activity was recovered to over 60%. Results There were no significant difference between these 2 groups in the sex, age, amount of the poisonous substance taken, and the time interval between poison taking and hospital visit. In the penehyclidine hydrochloride group only 1 case was complicated by intermediate syndrome and 27 cases had recovered; and in the control group 2 cases had repeat attacks,5 cases suffered from atropine poisoning, 3 cases were complicate by intermediate syndrome, and 23 cases were cured, There was a significant difference in the rate of complications between the two groups (P<0.01). Conclusion With significantly less side effects, penehyclidine Hydrochloride is better than atropine in treating AOPP.

关 键 词：急性有机磷农药中毒 阿托品 长托宁 

分 类 号：R[医药卫生]