卒中亚型急性期严重程度的影响因素  

The Influencing Factors of the Severity in Stroke Patients with Different Subtypes in Acute Period

作　　者：廖琦[1] 周冀英[2] 谭戈[2] 

机构地区：[1]中国人民解放军第四五二医院神经内科,四川省成都市610021 [2]重庆医科大学附属第一医院神经内科

出　　处：《中国卒中杂志》2007年第10期825-828,共4页Chinese Journal of Stroke

基　　金：重庆市卫生局重点资助项目(99-1001);国家自然科学基金(30370493)

摘　　要：目的分析卒中患者入院时的神经功能缺损程度评分(NFDS)与颅内压(ICP)、脑灌注压(CPP)等多种临床因素的相关性。方法对72例脑梗死患者及57例脑出血患者入院时的NFDS与病灶体积、ICP、CPP、血压、血脂、血糖、纤维蛋白原、发病时间、既往史评分、性别等作单因素相关分析,并在此基础上进一步作多元逐步回归分析。结果经多元逐步回归分析,脑梗死患者入院时NFDS与CPP(P=0.06)、发病后时间(P=0.05)、梗死体积(P<0.01)密切相关;脑出血患者入院时NFDS与ICP(P=0.02)及脑出血的体积(P<0.01)密切相关。结论病灶体积是脑梗死与脑出血患者入院时NFDS共同的影响因素,CPP在脑梗死患者中所占的权重较大,ICP在脑出血患者中所占的权重较大。Objective To analyze the relationship between the neurological functional defi cit scale(NFDS) and multiple clinical factors in acute stroke patients. Methods Total 129 patients were selected for the study (72 cases with cerebral infarction and 57 cases with intracerebral hemorrhage).The NFDS was used to evaluate the severity of neurological impairment. The relationship between the NFDS on admission and multiple clinical factors, including volume of focus, intracranial pressure (ICP), cerebral perfusion pressure(CPP), blood pressure, blood lipids, glucose, f ibrinogen, the interval from onset, past history score and gender, et al, was analyzed with Pearson correlation and multiple stepwise regression. Results In the cerebral infarction (CI) patients, the CPP, volume of focus and the interval from onset were independently associated with the extent of NFDS. While the ICP and volume of focus were independently associated with the extent of NFDS in the intracerebral hemorrhage(ICH) patients. Conclusion The volume of focus is the commonly influencing factor of NFDS in both CI and ICH patients. CPP has more important signifi cance to CI patients and the same as ICP to ICH patients.

关 键 词：卒中 亚型 神经功能缺损程度评分 颅内压 脑灌注压 

分 类 号：R743[医药卫生—神经病学与精神病学]