肝动脉化疗栓塞联合静脉注射三氧化二砷治疗原发性肝癌疗效探讨  

Efficacy of transcatheter arterial chemoem-bolization combined with arsenic trioxide in treatment of primary liver cancer

作　　者：王向明[1] 李凯滨[1] 

机构地区：[1]广东省肇庆市第一人民医院肿瘤科,526021

出　　处：《中国实用医药》2007年第15期15-17,共3页China Practical Medicine

摘　　要：目的 探讨肝动脉化疗栓塞联合全身静脉推注三氧化二砷(AS2O3)治疗原发性肝癌的近期疗效.方法 对32例中晚期原发性肝癌病人采用常规药物经皮肝动脉化疗栓塞治疗,间隔4周1周期,2～3个周期后观察疗效.同时给予三氧化二砷注射液10～15 mg静脉滴注,1次/d,连用14 d,间隔2周重复.结果 近期疗效,均按要求完成2～3个周期,随访1年以上,PR 13例,NC 14例,PD 5例,总有效率40.6%,临床获益率为84.4%.生活质量,改善18例(56.3%),稳定11例(34.4%).不良反应少.结论 肝动脉化疗栓塞(TACE)联合静脉推注三氧化二砷治疗中晚期原发性肝癌近期疗效较好,毒不良反应少.Objective To investigate the short term efficacy of transcatheter arterial chemoem-bolization (TACE) combined with arsenic trioxide(AS2O3) on treatment of primary liver cancer. Methods Thirty-two patients with advanced primary liver cancer underwent routine hepatic arterial chemoembolization,which administered every 4 weeks as a chemotherapy cycle and therapeutic effect were observed after 2～3 cycles. Meanwhile, 10～15 mg AS2O3 were intravenously guttae once a day for 2 weeks and repeated after 2 weeks. Results All patients were accomplished for 2～3 chemotherapy cycles according to request. Following-up for more than one year, Gross efficiency rate was 40.6% and total response was 84.4% with 13 cases of partial response (PR) , 14 cases of no changes (NC) and 5 cases of progressive disease(PD).Quality of life improved in 18 cases(56.3%) and stabilized in 11 cases(34.4%).Few side effects was observed. Conclusion TACE combined with arsenic trioxide on treatment of primary liver cance is good effective and toxicity is few.

关 键 词：肝肿瘤 肝动脉化疗栓塞 三氧化二砷 

分 类 号：R735.7[医药卫生—肿瘤]