围手术期肠内免疫营养对胃肠道肿瘤患者细胞免疫功能的影响  

作　　者：邓升健 

机构地区：[1]广东省江门市新会区司前医院外科,529000

出　　处：《中国实用医药》2007年第21期117-118,共2页China Practical Medicine

摘　　要：目的评价围手术期运用肠内免疫营养对胃肠道恶性肿瘤患者术后免疫功能的影响。方法40例患者被随机分成免疫营养组和普通营养组,每组各20例。于术前5d、术后4、8d检测T细胞亚群CD3+,CD4+,CD8+,CD4+/CD8+及NK细胞CD56+的数目,记录术后各种并发症种类和平均住院日。结果与术前比较,两组患者术后第1天各项免疫指标均有不同程度下降(P<0.05),免疫营养组术后第8天各项指标均回复术前水平(P>0.05),而普通营养组各项指标还徘徊在较低水平(P<0.05);与对照组比较,免疫营养组术后第1天的CD3+、CD4+、CD8+和CD56+明显高于普通营养组(P<0.05)。结论围手术期积极给予肠内免疫营养支持,可以显著改善胃肠道肿瘤患者细胞免疫功能,促进患者早日康复。Objective To investigate the effects of enteral immunonutrition on perioperation T-lymphocyte subsets and natural killer cells for patients received gastroenter tumor.Methods 40 patients with gastroenter tumor were randomly divided into two groups,20 patients were in each group.Peripheral venous blood samples were taken on preoperative day 5 and postoperative day 4 and 8 for determination of CD3+,CD4+,CD8+,CD4+/CD8+ and CD56+.Result On postoperative day 4 and 8,most immune variables in the immune nutrition group were significantly higher than those in the standard group(P<0.05).In the immune nutrition group,there were markedly fewer patients who experienced postoperative complications and shorter days of hospital stay compared with standard group(P<0.01).Conclusion The perioperative administration of enteral immunonutrition can improve the inhibition effects because of operation,and promote to recover the immunologic function for gastroenter tumor patient.

关 键 词：胃肠道肿瘤 细胞免疫 肠内免疫营养 

分 类 号：R735[医药卫生—肿瘤]