中药解郁丸与万拉法新治疗首发抑郁症疗效的对照研究  

Controlled Study on Efficacy Jieyu Pill and Venlafaxine in Treating the first onset Depression

作　　者：徐素伟[1] 关恒永[1] 王克强[1] 李炜青[1] 

机构地区：[1]河北省荣军医院,071000

出　　处：《中国实用医药》2007年第24期28-29,共2页China Practical Medicine

摘　　要：目的观察中药解郁丸治疗首发抑郁症的临床疗效及不良反应。方法通过随机对照试验研究,共纳入解郁丸组首发抑郁症患者22例,万拉法新组19例。于用药前及用药后14、28、42d分别采用HAMD抑郁量表评定药物的疗效,应用自制不良反应量表评定不良反应。结果解郁丸组治疗抑郁症的显愈率为68.18%,万拉法新组显愈率为73.68%,两组间的显愈率差异无统计学意义(P>0.05)。两组在治疗前与治疗后14、28、42d用HAMD量表评定对比均差异有统计学意义(P<0.05)。解郁丸组有3例(13.64%)出现轻度不良反应较万拉法新组出现的副反应10例(52.63%)显著为低(χ2=11.11,P<0.01)。结论解郁丸组治疗首发抑郁症与万拉法新组对比疗效相当,但不良反应明显少于万拉法新。Objective To investigate the clinical efficacy and the side-effects of Jieyu Pill(JYP)in treating the first onset depression.Methods The randomized controlled study was conducted in 22 patients in the treated group and 19 patients in the control group treated with venlafaxine(Ven).The efficacy of treatment was evaluated before treatment and 14,28,and 42 days after treatment,with Hamilton depression rating scale,self-made side effect scale and clinical global impression.Results JYP was effective in treating depression,the markedly effective rate being 68.18%,corresponded to that of Ven(73.68%).After treatment,the scores assessed by HAMD were all lower than those before treatment(P<0.05)respectively,but comparision between the two groups showed insignificant difference(P>0.05).However,the side effects of JYP was significantly lower than that of Ven(χ2=11.11,P<0.01).Conclusion JYP in treating the first onset depression shows the efficacy corresponded to that of Ven and with less the sida-effects.

关 键 词：解郁丸 万拉法新 首发抑郁症 不良反应 

分 类 号：R749.4[医药卫生—神经病学与精神病学]