抑癌基因PTEN在膀胱移行细胞癌中的表达及意义  

Expression and significance of PTEN in bladder transitional cell carcinoma

作　　者：赵海岩[1] 杨光天[1] 张志刚[1] 方毅[1] 

机构地区：[1]江苏省徐州医学院附属连云港医院泌尿外科,222002

出　　处：《中国实用医药》2007年第34期4-6,共3页China Practical Medicine

摘　　要：目的探讨抑癌基因PTEN在膀胱移行细胞癌中的表达及临床意义。方法采用PCR法观察40例膀胱移行细胞癌标本中PTEN的表达情况。结果40例膀胱移行细胞癌组织中9例(22.5%)PTEN表达阳性。随着肿瘤分期的进展PTEN的改变有增高的趋势但与肿瘤的分级无显著相关性。结论PTEN异常表达在膀胱移行细胞癌的进展中有重要作用,PTEN基因可作为评价膀胱移行细胞癌进展及预后的指标。Objective To investigate the expression of PTEN in bladder transitional cell carcinoma(BTCC)and its clinical significance.Methods Tumor samples from 40 patients with BTCC were analyzed its relationship with PTEN by PCR.Results The positive rate of PTEN was 22.5% in bladder transitional cell carcinoma.The result was not associated with grade of the tumor.The positive rate of PTEN was associated with stage of the tumor.Conclusion The abnormal expression of PTEN may play an important role in the development of bladder transitional cell carcinoma.The measurement of PTEN may have a guiding significance in BTCC.

关 键 词：膀胱肿瘤 PTEN 

分 类 号：R737.14[医药卫生—肿瘤]