Coronary artery disease in Chinese adults with type 2 diabetes mellitus estimated by electron beam computed tomography and electron beam computed tomography angiography  

作　　者：Chen Huang Minwen Zheng Xiaoming Wang Jianyuan Gao Hua Meng Liping Wu Rong Li Hui Su Hua Zhang Ronghuai Zhang 

机构地区：[1]The Second Department of Geriatrics,Xijing Hospital,the Fourth Military Medical University,Xi''an 710032,China [2]Department of Radiology,Xijing Hospital,the Fourth Military Medical University,Xi''an 710032,China

出　　处：《Journal of Geriatric Cardiology》2007年第3期155-161,共7页老年心脏病学杂志(英文版)

摘　　要：Objective To assess the prevalence and risk of coronary artery disease(CAD)in Chinese adults with type 2 diabetes mellitus(T2DM)using electron beam computed tomography(EBCT)and EBCT angiography(EBCTA).Methods:Ninety-four cases were enrolled in this study including diabetes(n=28),impaired glucose tolerance(IGT,n=30),coronary heart disease(CHD,n=11),and control(n=25).Cardiac EBCT plain scanning and EBCTA were performed on all of these subjects to evaluate coronary artery calcifica-tion(CAC)scores,and number of segments of stenosed coronary arteries.Both CAC and/or coronary artery stenosis were defined as patients with coronary artery lesions(CAL).Results CAC scores were not different with the control,diabetes,IGT,or CHD(P>0.05)groups.Compared to control(0.520±1.295),more stenosed coronary arteries segments(P<0.05)were detected in diabetes(2.964±1.915),IGT(2.200±2.024),and CHD(2.273±1.679).Number of stenosed artery segments were correlated with age(r=0.215,P=0.019),postprandial glucose(r=0.224,P=0.015),total cholesterol(r=0.323,P=0.000),and duration of diabetes(r=0.208,P=0.004).The incidences of CAL in diabetes(96.43%),IGT(93.33%),and CHD(90.91%)was substantially higher than that in normal control(56.00%,P<0.01).The odds ratio of CAL associated with having diabetes was estimated to be 7.514(95%CI:1.885-63.778).Conclusions Coronary artery lesions are prevalent in Chinese adults with type 2 diabetes,implying a high CAD risk.EBCTA holds potential in depicting the details of CAL and can be used to track the progression of CAD in diabetes patients.

关 键 词：DIABETES coronary artery calcification coronary artery stenosis electron-beam computed tomography(EBCT) 

分 类 号：R[医药卫生]