肿瘤血管生成的靶向调控及其药物研究进展  

Targeted control of tumor angiogenesis and the development of its inhibits

作　　者：王振宇[1] 陈晓鹏[1] 

机构地区：[1]皖南医学院弋矶山医院普外科,芜湖241000

出　　处：《中国现代药物应用》2007年第9期67-69,共3页Chinese Journal of Modern Drug Application

摘　　要：肿瘤血管生成(Tumor Angiogenesis)对大多数实体瘤的生长和转移具有重要意义,是多步骤多因素参与复杂的病理过程。选择肿瘤血管生成中的一些关键环节或参与的重要因子作为靶点,研制应用特异性肿瘤血管生成抑制剂或抗体,以靶向调控肿瘤血管生成,控制肿瘤的生长和转移,达到治疗肿瘤的目的。本文对近年来肿瘤血管生成机制和肿瘤血管生成抑制剂的研究进展进行综述。Tumor Angiogenesis,a complicated pathologic process,plays an important role in most solid tumors growth and metastasis.Choosing some key measures or some important factors as therapeutic targets,researching and using specific antibody or tumor angiogenesis inhibitors control growth and metastasis of tumor to attain the accomplishment of treating the tumor through targeted-controlling tumor angiogenesis.We present a review on recent research related to the mechanism of tumor angiogenesis and the development of tumor angiogenesis inhibits.

关 键 词：肿瘤血管生成 靶向调控 肿瘤血管生成抑制剂 

分 类 号：R730.2[医药卫生—肿瘤] R979.1[医药卫生—临床医学]