得必泰联合奥美拉唑、奥硝唑治疗消化性溃疡临床观察  

Clinical observation of The Combined Use of Bismutll Aluminate Compound,Omeprazole,Ornidazole for Treating Peptic Ulcer

作　　者：宋宝辰 李宁[1] 周培兰[1] 孙常春[1] 李建波[1] 董峰[1] 王培利[1] 

机构地区：[1]山东省郯城县第一人民医院,276100

出　　处：《中国现代药物应用》2007年第11期16-17,共2页Chinese Journal of Modern Drug Application

摘　　要：目的探讨以质子泵抑制剂奥美拉唑为基础加两种不同抗生素及铋制剂的一周三联疗法治疗消化性溃疡及根除幽门螺杆菌(Hp)感染的疗效。方法将我院消化内科2006年3月至2007年10月期间经电子胃镜确诊的消化性溃疡(包括胃溃疡和十二指肠球部溃疡),且快速尿素酶试验阳性的168例门诊及住院患者随机分为两组:治疗组85例,治疗组给予得必泰2600mg,3次/d,奥美拉唑20mg,2次/d,奥硝唑500mg,2次/d。对照组:丽珠得乐220mg,2次/d,奥美拉唑20mg,2次/d,替硝唑500mg,2次/d。两组同时进行7d的正规治疗,4周后复查电子胃镜和快速尿素酶试验,根据消化性溃疡的内镜分型及尿素酶试验结果判断疗效。结果治疗组总有效率为97.64%,对照组总有效率为80.72%,差异有显著性(P<0.01)。结论由得必泰(复方铝酸铋颗粒)、奥硝唑组成的一周三联疗法可获得较好的治疗效果和较高的Hp根除率,且价廉安全实用。Objective To study the effect of combined use of Bismutll Aluminate Compound,Omeprazole and Ornidazole in treatment of peptic ulcer.Methods my digestion internal medicine department in March,2006-October,2007 period Have diagnosed the Peptic ulcer (including GU and DU)with gastroscope and the quickly urease test.168 patients with peptic ulcer( HP positive) were divided into two e groups stochastically.The 85 patients of the treatment group was given omeprazole 20 mg+Ornidazole500 mg two times a day+Bismutll Aluminate Compound three times a day for seven days.The 85 patients of the control group was given De-Nol 220 mg2four times a day+omeprazole 20 mg+Tinidazole 500 mg two times a day for seven days.Results The total effectiveness of treatment group is 97.64%,comparison the control group is 80.72%,The results between two groups were significant difference(χ2=12.57,P<0.05).Conclusion The conclusion by Bismutll Aluminate Compound,Omeprazole,Ornidazole trigeminy therapy be possible to obtain the better result and higher Hp eradicating rate,also the moderateprice safe is practical.

关 键 词：得必泰 奥硝唑 奥美拉唑 消化性溃疡 幽门螺杆菌 

分 类 号：R573.1[医药卫生—消化系统]