Radiobiological response of human hepatoma and normal liver cells exposed to carbon ions generated by Heavy Ion Research Facility in Lanzhou  

作　　者：YANG Jianshe1,2, LI Wenjian1, JIN Xiaodong1, JING Xigang1, GUO Chuanling1, WEI Wei1 & GAO Qingxiang3 1. Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China 2. Life Science School of North West Normal University, Lanzhou 730070, China 3. Life Science School of Lanzhou University, Lanzhou 730000, China 

出　　处：《Science China(Physics,Mechanics & Astronomy)》2006年第1期72-76,共5页中国科学：物理学、力学、天文学（英文版）

基　　金：the National Natural Science Foundation of China (No. 10335050); National Basic Research Program of China (Grant No. 2003CCB00200).

摘　　要：Human hepatoma and normal liver cells were irradiated with 12C6+ ion beams (LET = 96.05 keV/μm) and γ-rays at Heavy Ion Research Facility in Lanzhou (HIRFL). The chromatid breaks and break types were detected using the premature chromosome con- densation technique. Our experimental results showed that chromatid breaks seem to have a good relation with 12C6+ absorbed dose and 12C6+ are more effective to induce chromatid breaks as compared to the γ-rays. For 12C6+ ion irradiation the major break was isochromatid break, while chromatid breaks were dominant for γ-ray irradiation. We also observed that the Relative Biology Effectiveness (RBE) of 12C6+ ion is about 2.5 times higher than that of γ-rays.Human hepatoma and normal liver cells were irradiated with 12C6+ ion beams (LET = 96.05 keV/μm) and γ-rays at Heavy Ion Research Facility in Lanzhou (HIRFL). The chromatid breaks and break types were detected using the premature chromosome con- densation technique. Our experimental results showed that chromatid breaks seem to have a good relation with 12C6+ absorbed dose and 12C6+ are more effective to induce chromatid breaks as compared to the γ-rays. For 12C6+ ion irradiation the major break was isochromatid break, while chromatid breaks were dominant for γ-ray irradiation. We also observed that the Relative Biology Effectiveness (RBE) of 12C6+ ion is about 2.5 times higher than that of γ-rays.

关 键 词：biological response  tumor cell  NORMAL cell  heavy ion HIRFL. 

分 类 号：R735.7[医药卫生—肿瘤]