ApoAI在急性心肌梗死发病中的意义及他汀类药物干预的价值研究  

Study about the relation between ApoA I and acute myocardial infarction and effect of Simvastation

作　　者：于安忠[1] 刘兵[1] 董颖[1] 王焕勤[1] 

机构地区：[1]山东省济南市第四人民医院心内科,济南250031

出　　处：《中国医药导报》2006年第6期17-18,共2页China Medical Herald

摘　　要：目的研究ApoAI与急性心肌梗死之间的关系及他汀类药物对ApoAI异常的治疗价值。方法将研究病例分成三组:急性心肌梗死组(AMI组)、稳定性心绞痛组(SAP组)、对照组,比较入院时ApoAI、HDL-C在三组间的差异。将AMI组根据药物剂量分成A组和B组,比较治疗前后ApoAI、HDL-C变化值在两组间的差异。结果ApoAI在三组间两两比较均有显著性差异;HDL-C在三组间两两比较均无统计学差异。治疗后ApoAI在A组与B组均增加,P<0.05;A组比B组ApoAI增加更显著,P<0.05。治疗后HDL-C在A组与B组增加均不显著,P>0.05。结论低ApoAI血症与冠心病具有相关性,在急性心肌梗死的患者中ApoAI减低更明显。低ApoAI血症与冠心病的关系较低HDL-C血症显著。短期(1周)应用辛伐他汀可以升高ApoAI浓度。Objective To study the relation between ApoA I and acute myocardial infarction and effect of Simvastatin.Methods The patients enrolled in this study were divided into three guoups:AMI group for patients with acute myocardial infarction,SAP group for stable angina pectoris and control group.To check the differences of ApoA I、HDL-C between the three groups.AMI group were divided into A group and B group according to the drug dosage,to contrast the changes of ApoA I、HDL-C between the two groups after therapy.Results The differences of ApoA I between the three groups were significant,but the differences of HDL-C didn't exist.ApoA I of A group and B group all increased after therapy,P<0.05;ApoA I of A group increased more than that of B group after therapy,P<0.05;HDL-C of A or B group did not increased,P>0.05.Conclusion ApoA I is relative with coronary heart disease,it decreases apparently in patients with acute myocardial infarction.The relation between ApoA I and coronary heart disease is significant than HDL-C.ApoA I increases by using Simvastatin for a short time(1 week).

关 键 词：载脂蛋白 急性心肌梗死 辛伐他汀 

分 类 号：R[医药卫生]