噻奈普汀合用黛力新治疗中重度抑郁症疗效对比研究  

作　　者：胡萌[1] 李臻[1] 任兰振[1] 

机构地区：[1]中山大学附属东华医院,广东东莞523110

出　　处：《中国医药导报》2006年第18期19-20,共2页China Medical Herald

摘　　要：目的观察噻奈普汀合用黛力新治疗中重度抑郁症疗效。方法53例中重度抑郁症患者随机分成两组。分别给予噻奈普汀(24例)和噻奈普汀合用黛力新治疗(29例)4周。采用汉密尔顿抑郁量表(HAMD)评定临床疗效,并采用需要处理的不良反应反应量表(TESS)评定安全性。结果噻奈普汀组和噻奈普汀合用黛力新组总有效率分别为58.33%和86.21%。两组差异有显著性(P<0.05)。噻奈普汀合用黛力新组在治疗4周时的HAMD减分率均高于噻奈普汀组,并且差异有显著性(P<0.01)。两组均有口干、头痛、便秘等不良反应,两组不良反应发生率对比,差异无显著性(P>0.05)。结论噻奈普汀合用黛力新治疗中重度抑郁症具有良好的疗效和安全性,且在一周内明显起效。Objetive To observe the curative effect of treating midrange and major Depressive Disorder by combination of Tianeptine and Deanxit. Methods We randomly divide a total of 53 patients with midrange and major Depressive Disorder into 2 groups. one group of 24 patients is treated only by Tianeptine for four weeks, the other of 29 patients is treated by combination of Tianeptine and Deanxit for the same period. We evaluate the clinical curative effect according to HAMD and the safety to TESS. Results The total effective rate of the group treated only by Tianeptine is 58.33%,while the other is 86.21%.The difference between the two groups is of great significance (P <0.05). The decrease score rate of the group treated by combination of Tianeptine and Deanxit for one month(four weeks) is much higher than the group only by Tianeptine. Moreover the difference is noticeable(P <0.01).All the patients in the study have the symptoms of dry mouth?headache and constipation etc. It is no is of great significance (P >0.05). Conclusions The method of treating midrange and major Depressive Disorder by combination of Tianeptine and Deanxit owns satisfactory curative effect and safety. And it will have evident therapeutic effect among one week.

关 键 词：抑郁症 噻奈普汀 黛力新 

分 类 号：R[医药卫生]