多肿瘤标志物蛋白芯片检测系统在临床中的应用  

作　　者：陈莉[1] 彭剑雄[2] 周细国[3] 

机构地区：[1]中南大学湘雅医学院 [2]中南大学湘雅医学院医学检验系,硕士研究生导师湖南长沙410013 [3]湖南省怀化市第一人民医院,湖南怀化418000

出　　处：《中国医药导报》2006年第29期29-31,共3页China Medical Herald

摘　　要：目的探讨多肿瘤标志物蛋白芯片检测系统(简称C-12)对肿瘤的筛查和常见的5种肿瘤检出的优势。方法用该检测系统测定分析500例恶性肿瘤患者,150例良性疾病患者和1600例健康体检者血清12种常见肿瘤标志物(CA199、NSE、CEA、CA242、CA125、CA153、AFP、Ferritin、free-PSA、PSA、β-HCG及HCH)的水平。结果恶性肿瘤组的阳性率显著高于良性疾病组和健康体检组。C-12对相关5种恶性肿瘤检出的灵敏度高于肿瘤标志物单项指标,对健康人群检测的特异性为95%,对健康人群肿瘤的检出率为0.2%。结论运用蛋白芯片技术联合检测多种肿瘤标志物可以明显提高恶性肿瘤诊断的敏感性,同时也可以作为无症状人群的早期肿瘤普查手段之一,尤其对肿瘤高危人群的防癌普查具有一定的意义。Objective To investigate the advantages of multi-tumor marker protein chip assistance diagnostic system for screening over 5 kinds of cancers and the its specificity and sensitivity in detection of non-cancer subjects and healthy persons. Methods The serum levels of 12 common tumor markers ,including CA199、NSE、CEA、CA242、CA125、CA153、AFP、Ferritin、free-PSA、PSA、β-HCG and HCH ,were measured with the detective system in 500 malignant tumor patients,150 patients with benign disease and 1 600 healthy examinations .Results The positve rates were in malignant tumor,benign disease and healthy groups,respectively. The malignant tumor group had significantly higher positve rate than that of the controls. The sensitivity of the multi-tumor marker protein chip assistance diagnostic system was higher in detection of the 12 tumor markers than that in detection of a single tumor marker and its specificity in detection of healthy persons was 95%. And the tumor -detecting rate during health check-up was 0.2%. Conclusions Combined measurement of multiple serum tumor markers using protein biochip technique can significantly increase the diagnostic sensitivity for malignant tumor,but also can be used as an earlier period tumor surveying tool to symptomless people,especially to high risk people .

关 键 词：肿瘤12项标志物 蛋白芯片 

分 类 号：R[医药卫生]