焦虑症、抑郁症的关联性负变  

Analysis of contingent negative variation between patients with anxiety disorder and depression

作　　者：任清涛[1] 蒲金玉[1] 祝强[1] 崔英光[1] 

机构地区：[1]山东淄博市精神病医院,淄博255120

出　　处：《神经病学与神经康复学杂志》2006年第4期219-221,共3页Journal of Neurology and Neurorehabilitation

基　　金：山东省淄博市科技局;淄博市精神病医院科研基金

摘　　要：目的探讨焦虑症(AD)和抑郁症的关联性负变(CNV)变异。方法应用 Nicolet Bravo 脑诱发电位仪,采用光和声成对刺激以及反应时间技术,记录了37例 AD 患者的 CNV,并与36例健康成人(NC)和32例抑郁症患者的 CNV 进行比较。结果AD 和抑郁症组波形不规则,CNV-Ⅱ型尤甚。AD 组、抑郁症组及 NC 组在潜伏期 M_2及波幅 M_1、M_2差异有显著性(P<0.05～0.01)。与 NC 组相比,抑郁症组波幅降低和潜伏期延迟。AD 组呈同样趋势。结论 CNV 是评定 AD 患者和抑郁症患者大脑综合功能的有效工具,值得临床推广应用。Objective In order to investigate the variations of contingent negative variations(CNV)of patients with anxiety disorder(AD)and depression,the present study was initiated.Methods Event-related potentials were recorded from 37 AD patients using a Nicolet Bravo Instrument,and were compared with those of 32 patients with depression and 36 normal controls(NC).Results AD and depression patients presented irregular CNV wave- form,especially CNV-Ⅱ type.A significant difference of CNV among 3 groups was found in latency and amplitudes (M_2,M_2)(P<0.05～0.01).Compared with NC group,depression group showed delayed M_2 latency and de- creased M_2 amplitude(P<0.05～0.01).Compared with NC group,AD group showed delayed increased amplitude. Conclusion CNV is a useful tool for assessing the brain malfunction of AD and depression,and its clinical applica- tion is recommended.

关 键 词：关联性负变 焦虑症 抑郁症 

分 类 号：R749.7[医药卫生—神经病学与精神病学] R749.4[医药卫生—临床医学]