亚甲基四氢叶酸还原酶基因C677T多态性与脑梗死的关系  

The Relationship between the C677T Porlymorphism in the Methylenetetrahydrofolate Reductase Gene and Cerebral Infarction

作　　者：周君[1] 李晓霞[2] 

机构地区：[1]牡丹江医学院红旗医院神经内科,黑龙江省牡丹江市157000 [2]牡丹江医学院预防医学教研室

出　　处：《中国卒中杂志》2006年第4期271-273,共3页Chinese Journal of Stroke

基　　金：黑龙江省自然科学基金(D-0357)

摘　　要：目的探讨亚甲基四氢叶酸还原酶(MTHFR)基因C677T多态性与脑梗死的关系。方法应用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)方法检测72例脑梗死患者和69例对照者的MTHFR基因C677T多态性分布,并进行对比分析。结果对照组MTHFR基因型CC、CT、TT频率分别为11．6%、44．9%和43．5%,脑梗死组分别为15．3%、50．0%和34．7%,两组各基因型分布间差别无显著性意义(P＞0．05);对照组等位基因C、T频率分别为34．0%、65．9%,脑梗死组分别为40．3%、59．7%,两组等位基因的分布间差别无显著性意义(P＞0．05)。结论本研究未发现MTHFR基因C677T多态性与脑梗死之间存在相关关系,应进一步行大样本的流行病学研究,以明确二者的相关性。Objective To study the relationship between the C677T polymorphism of methylenetetrahydrofolate reduc- tase (MTHFR) gene and cerebral infarction.Methods MTHFR gene C677T porlymorphism was detected in 141 subjects,in- cluding 69 in control (CON) group and 72 in cerebral infarction (CI) group by PCR-RFLP technique.Results No signifi- cant difference in genotype frequencies and allele frequencies of MTHFR gene was found between the CON group and CI group (P＞0.05).Conclusion No association between MTHFR gene C677T porlymorphism and CI is noted in present study.

关 键 词：亚甲基四氢叶酸还原酶基因 聚合酶链反应-限制性片段长度多态性 脑梗死 

分 类 号：R743.3[医药卫生—神经病学与精神病学]