缺血性脑卒中患者抑郁状态与影像学改变的关系  

The Relationship between Depression after Ischemic Stroke and Neuroimaging Findings

作　　者：汤剑萍[1] 李焰生[1] 林岩[1] 李红伟[1] 徐群[1] 

机构地区：[1]上海交通大学医学院附属仁济医院神经内科,上海市200127

出　　处：《中国卒中杂志》2006年第7期466-469,共4页Chinese Journal of Stroke

基　　金：上海市科委重大攻关项目(03DZ19704);上海市卫生局课题(034078)

摘　　要：目的探讨缺血性脑卒中患者抑郁状态与卒中部位、病灶体积及脑白质病变之间的关系。方法对59例缺血性脑卒中患者随访12～18个月(平均13个月),采用24项Hamilton抑郁量表(HAMD)对患者进行评分,得分<8分为无抑郁症状,8～17分为抑郁状态,>17分为抑郁。于入组及随访结束时分别行头颅磁共振成像(MRI)及Hamilton评分检查。结果抑郁的发生与患者脑深部白质病变(DWML)、脑室周围白质病变(PWML)的程度无关及卒中病灶部位无关(P均>0.05),且与随访期间新发病灶无关(P>0.05),与病灶体积亦无关(P>0.05)。结论缺血性脑卒中患者卒中后抑郁的发生与卒中病灶部位及脑白质病变程度无关。Objective To determine the relationship between post-stroke depression (PSD) and neuroimaging findings in a well-defined ischemic stroke cohort. Methods Total 59 patients with ischemic stroke were followed-up for about 13 months. The patients had been regularly tested by the Hamilton Depression Rating Scale for Depression(HAMD).The patients were divided into three groups according to their scores of HAMD with cutoff point at<7, 8～17, and>17.The patients were also taken magnetic resonance imaging (MRI) examinations at baseline and at end of follow-up. Results There were no significant differences in the deep white matter lesions, the periventricular white matter lesions or the lesion location ( all P>0.05 ) between depressive and non-depressive patients. The volume of infarction was not associated with PSD( P>0.05). Conclusion In present study, the relationship between PSD and lesion location or white matter lesion can’t be found.

关 键 词：卒中后抑郁 病灶部位 脑白质病变 

分 类 号：R749.1[医药卫生—神经病学与精神病学]