失代偿性肝硬化患者血清VEGF、TGF-β_1、TNF-α检测及临床意义  

Detection and significance of serum VEGF,TGF-β_1,TNF-α in patients with decompensated liver cirrhosis

作　　者：章幼奕[1] 邹美银[1] 吴月平[1] 施旦华[1] 陶虎[1] 高金华[1] 

机构地区：[1]江苏省南通市第三人民医院感染科,南通226006

出　　处：《南通大学学报（医学版）》2009年第4期244-246,共3页Journal of Nantong University(Medical sciences)

基　　金：南通市社会发展科技计划项目(S5016)

摘　　要：目的:检测失代偿性肝硬化(DLC)患者血清血管内皮生长因子(VEGF)、转化生长因子β1(TGF-β1)、肿瘤坏死因子-α(TNF-α)水平,探讨血清VEGF、TGF-β1、TNF-α对DLC预后判断的意义。方法:选择DLC患者86例,同步测定血清VEGF、TGF-β1、TNF-α,分析三者水平变化与肝脏损伤程度的关系。结果:DLC患者血清VEGF、TGF-β1、TNF-α均明显高于健康组,随着肝硬化、肝癌发展,TGF-β1、TNF-α水平逐渐下降(P<0.05,P<0.01);发生慢加亚急性肝衰竭(SACLF)患者VEGF、TNF-α水平高于慢性肝衰竭(CLF)患者(P<0.05);中晚期SACLF患者VEGF、TNF-α高于早期,早中期患者TGF-β1水平低于晚期(P<0.05);死亡患者血清VEGF、TGF-β1水平明显高于病情好转者(P<0.01),TNF-α低于病情好转者(P<0.05)。结论:DLC患者血清VEGF、TGF-β1、TNF-α的水平与疾病的严重程度及预后密切相关,它们在DLC发生发展过程中可能起重要作用。Objective:To evaluate the significance of serum vascular endothelial growth factor (VEGF),transforming growth factor-β1 (TGF-β1) and tumor necrosis factor-α (TNF-α) in predicting prognosis of patients with decompensated liver cirrhosis (DLC). Methods:Serum VEGF,TGF -β1,and TNF-α were detected in 86 patients with DLC. The correlations between the changes of serum VEGF ,TGF-β1 and TNF-α and the degree of liver injury were analyzed. Results:The serum levels of VEGF,TGF-β1 and TNF-α were all higher than those o...

关 键 词：肝硬化 失代偿 血管内皮生长因子 转化生长因子Β1 肿瘤坏死因子-α 

分 类 号：R575.2[医药卫生—消化系统]