三磷酸腺苷法肿瘤药敏检测在膀胱癌化疗中的临床研究  

A clinical research on adenosine triphosphate based tumour chemosensitivity assay in chemotherapy of bladder carcinoma

作　　者：李华镭[1] 何崇生[1] 朱惠君[2] 黄剑飞[2] 

机构地区：[1]南通大学附属医院泌尿外科,南通226001 [2]南通大学附属医院病理科,南通226001

出　　处：《南通大学学报（医学版）》2009年第5期334-335,338,共3页Journal of Nantong University(Medical sciences)

摘　　要：目的:采用三磷酸腺苷法对膀胱癌组织标本进行肿瘤药物敏感筛选,为化疗选择方案确定提供客观依据。方法:80例膀胱癌新鲜标本行原代培养,同时用6种化疗药物进行检测。结果:标本均顺利完成检测,可评估率为100%,单药强敏感率为甲氨蝶呤(15.00%)、阿霉素(37.50%)、丝裂霉素(31.25%)、顺铂(26.25%)、羟基喜树碱(41.25%),吡柔比星(56.25%),不同药物对膀胱癌的敏感程度有差异(P<0.01);不同个体对不同药物的敏感度差异有统计学意义(P<0.01)。结论:不同膀胱癌标本对化疗药物的敏感程度有明显不同,三磷酸腺苷法可为膀胱尿癌的化疗方案确定提供指导作用。Objective:To investigate the heterogeneity of chemosensitivity in carcinoma of bladder using adenosine triphosphate based tumour chemosensitivity assay(ATP-TCA) and the feasibility of individual chemotherapy.Methods:ATP-TCA was used to determine the effect of 6 single drugs in surgical specimens from 80 patients with carcinoma of bladder.Results:All these 80 specimens were detected successfully and the rate of evaluation was 100%.There were considerable differences in chemosensitivity among individuals.The ...

关 键 词：膀胱癌 三磷酸腺苷法 肿瘤药物敏感 化学治疗 

分 类 号：R737.14[医药卫生—肿瘤]