大豆异黄酮对去卵巢大鼠子宫内膜细胞增殖的影响  

Effects of genistein on proliferation of endometrium in ovariectomized rats

作　　者：吕斌[1] 张萍[2] 李振国[1] 何伟[3] 

机构地区：[1]河南省食品药品检验所,郑州450003 [2]郑州大学公共卫生学院社会医学与卫生事业管理教研室,郑州450001 [3]河南省医学科学研究所,郑州450052

出　　处：《郑州大学学报（医学版）》2009年第6期1256-1257,共2页Journal of Zhengzhou University(Medical Sciences)

摘　　要：目的:观察大豆异黄酮(GS)对去卵巢大鼠子宫内膜细胞增殖的影响。方法:30只成年雌性去卵巢大鼠于术后8d随机分为阴性对照组、GS(低、中、高)剂量组与阳性对照组,按2.0mL/kg分别腹腔注射蒸馏水、GS及雌二醇(E2),1次/d,连续注射3d。观察各组大鼠子宫内膜细胞有丝分裂数。结果:阴性对照组、阳性对照组及GS组细胞有丝分裂数差异有统计学意义(F=54.886,P<0.001),且阳性对照组与GS组均高于阴性对照组(P<0.05)。随GS剂量的升高,GS组细胞有丝分裂数增加(F=4.692,P=0.026)。结论:GS能加速去卵巢大鼠子宫内膜细胞的分裂和增殖,其在大鼠体内可能具有雌激素样作用。Aim:To study the effects of genistein(GS)on endometrium proliferation in ovariectomized rats.Methods:A total of 30 ovariectomized mature female SD rats were allocated into negative control group,(low,middle,high-dose GS)group,and positive control group,and were given normal saline,GS(0.02,0.10,and 0.50 mg/kg),and E2 for three days.The proliferative effects were evaluated by number of mitotic cells.Results:The number of mitotic cells in negative control group,positive control group,and GS group had significa...

关 键 词：大豆异黄酮 有丝分裂指数 雌激素样作用 增殖 大鼠 子宫内膜细胞 

分 类 号：R151[医药卫生—营养与食品卫生学]