围绝经期抑郁与女性激素水平的相关性  

Female sex hormone levels and peri-menopause depression disorder

作　　者：王梦欣[1] 宋冬玲[1] 崔明峰[1] 

机构地区：[1]山东大学齐鲁医院心理科,济南250012

出　　处：《山东大学学报（医学版）》2009年第8期122-124,共3页Journal of Shandong University:Health Sciences

基　　金：山东省教育厅科技计划项目(J06L74)

摘　　要：目的探讨围绝经期抑郁患者女性激素水平与抑郁的关系。方法选择围绝经期抑郁患者100例设为抑郁组,围绝经期无抑郁健康者100例设为对照组;采用汉密顿抑郁量表(HAMD,24项)评定临床抑郁症状,采用化学发光法检测血清雌二醇(E2)、孕酮(P)水平。结果抑郁组E2检测结果与对照组比较差异无统计学意义(18.28±11.65 vs 21.31±10.97,P>0.05);P检测结果与对照组比较差异有统计学意义(0.97±0.25 vs 0.48±0.26,P<0.05);E2/P比值与对照组比较差异有统计学意义(21.30±11.97 vs 37.71±15.27,P<0.01);HAMD评定结果与P呈正相关,与E2/P比值呈负相关。结论围绝经期抑郁者内源性激素水平与健康者不同,雌激素和孕激素调节功能的紊乱可能是围绝经期抑郁发病机制之一。Objective To investigate the correlation between peri-menopause depression disorder and female sex hormone levels.Methods 100 peri-menopausal women with depression disorder were assessed and 100 peri-menopause ones without depression disorder served as controls.The Hamilton Depression Scale was used to evaluate their depressive symptoms.Chemiluminescence Determination was adopted to determine the serum E2 and P levels.Result ① Level of E2 had no significant difference between the two groups(18.28±11.65 vs 2...

关 键 词：性激素 围绝经期 抑郁 

分 类 号：R749.42[医药卫生—神经病学与精神病学]